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Invitrogen
LIS1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-70188
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the N terminal region of human LIS1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homolog of Miller-Dieker gene; lissencephaly 1 protein; lissencephaly-1 protein; MGC25297; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; Pafaha/Lis1; PHFAH1B1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); platelet-activating factor acetylhydrolase 45kD subunit; platelet-activating factor acetylhydrolase IB subunit alpha; RP23-194P5.2; unnamed protein product
Gene Aliases: LIS-1; LIS1; LIS2; MDCR; MDS; Mdsh; MMS10-U; Ms10u; NudF; PAFAH; Pafaha
UniProt ID: (Human) P43034, (Mouse) P63005
Entrez Gene ID: (Human) 5048, (Mouse) 18472
establishment of mitotic spindle orientation
microtubule cytoskeleton organization
acrosome assembly
neuron migration
microtubule-based process
nuclear migration
chemical synaptic transmission
nervous system development
neuroblast proliferation
learning or memory
retrograde axonal transport
adult locomotory behavior
negative regulation of neuron projection development
stem cell division
transmission of nerve impulse
corpus callosum morphogenesis
hippocampus development
layer formation in cerebral cortex
cerebral cortex neuron differentiation
cerebral cortex development
actin cytoskeleton organization
forebrain development
microtubule organizing center organization
reelin-mediated signaling pathway
positive regulation of embryonic development
establishment of planar polarity of embryonic epithelium
cortical microtubule organization
positive regulation of axon extension
positive regulation of mitotic cell cycle
platelet activating factor metabolic process
vesicle transport along microtubule
brain morphogenesis
modulation of synaptic transmission
neuromuscular process controlling balance
microtubule sliding
positive regulation of cellular component organization
establishment of organelle localization
establishment of centrosome localization
auditory receptor cell development
positive regulation of dendritic spine morphogenesis
platelet activating factor catabolic process
regulation of microtubule cytoskeleton organization
cochlea development
microtubule cytoskeleton organization involved in establishment of planar polarity
regulation of postsynapse organization
ameboidal-type cell migration
positive regulation of cytokine-mediated signaling pathway
protein secretion
cell migration
osteoclast development
negative regulation of JNK cascade
nuclear envelope disassembly
centrosome localization
maintenance of centrosome location
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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