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Invitrogen
NCOA6 Polyclonal Antibody
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FIGURE: 1 / 3
NCOA6 Antibody (PA5-72896) in IHC (P)
Immunohistochemistry analysis of NCOA6 in mouse prostate and kidney. Samples were incubated with NCOA6 polyclonal antibody (Product # PA5-72896) using a dilution of 1:2,000.A) prostate tissue from a male mouse prostatitis. B) kidney from a mouse with pyelonephritis. A1 and B1, high magnification of A and B, respectively.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-72896
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A recombinant full-length human ASC-2/POP1 protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activating signal cointegrator 2; activating signal cointegrator-2; amplified in breast cancer 3; amplified in breast cancer protein 3; amplified in breast cancer-3 protein; cancer-amplified transcriptional coactivator ASC-2; coactivator for PPAR; coactivator; KIAA0181; KIAA0181; NRC RAP250; nuclear receptor coactivator RAP250; nuclear receptor-activating protein 250; nuclear receptor-activating protein, 250 kDa; nuclear receptor-interacting protein PIP23; peroxisome proliferator-activated receptor interacting protein; peroxisome proliferator-activated receptor interacting protein,PRIP; peroxisome proliferator-activated receptor-interacting protein; PPAR interacting protein PRIP; PPAR-interacting protein; thyroid hormone receptor binding protein; unnamed protein product
Gene Aliases: AIB3; ASC-2; ASC2; mKIAA0181; Ncoa7; NRC; PRIP; RAP250; TRBP
UniProt ID: (Human) Q14686
Entrez Gene ID: (Human) 23054, (Mouse) 56406
chromatin binding
transcription coactivator activity
protein binding
enzyme binding
estrogen receptor binding
retinoid X receptor binding
thyroid hormone receptor binding
protein domain specific binding
glucocorticoid receptor binding
identical protein binding
vitamin D receptor binding
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
chromatin-protein adaptor activity
histone methyltransferase binding
positive regulation of peptide secretion
chromatin organization
DNA-templated transcription, initiation
cellular response to DNA damage stimulus
brain development
heart development
regulation of gene expression
myeloid cell differentiation
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
labyrinthine layer blood vessel development
response to hormone
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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