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Invitrogen
Urocortin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-75189
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 80-124 of Human UCN.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Urocortin (UCN), a 40 amino acids neuropeptide widely distributed in the central nervous system (CNS), belongs to a family of structurally related peptides including corticotrophin releasing factor (CRF), sauvagine and urotensin I. Urocortin is derived from a larger precursor protein (pro-urocortin, also named corticotensin). Urocortin has biological actions similar to CRF such as stress-related endocrine, autonomic and behavioral responses in mammalian species. It is a potent stimulator of adrenocorticotropic hormone (ACTH) secretion by corticotroph cells from the anterior pituitary in vitro and in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: corticotensin; prepro-urocortin; UCN; urocortin, preproprotein
Gene Aliases: Mpv17; UCN1; UI; UROC
UniProt ID: (Human) P55089, (Mouse) P81615, (Rat) P55090
Entrez Gene ID: (Human) 7349, (Mouse) 22226, (Rat) 29151
startle response
response to oxidative stress
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
female pregnancy
learning or memory
feeding behavior
associative learning
aerobic respiration
positive regulation of gene expression
negative regulation of gene expression
response to auditory stimulus
positive regulation of cell growth
neuron projection development
negative regulation of appetite
response to estradiol
positive regulation of interleukin-6 production
positive regulation of collagen biosynthetic process
social behavior
vasodilation
drinking behavior
negative regulation of apoptotic process
positive regulation of vascular permeability
negative regulation of neuron apoptotic process
positive regulation of translation
positive regulation of DNA replication
negative regulation of blood pressure
negative regulation of cell size
positive regulation of transcription from RNA polymerase II promoter
negative regulation of hormone secretion
response to pain
response to glucocorticoid
positive regulation of corticotropin secretion
general adaptation syndrome
regulation of synaptic transmission, glutamatergic
positive regulation of cardiac muscle contraction
positive regulation of calcium ion import
positive regulation of cAMP/PKA signal transduction
negative regulation of feeding behavior
positive regulation of behavioral fear response
positive regulation of protein phosphorylation
positive regulation of peptidyl-serine phosphorylation
activation of protein kinase A activity
response to immobilization stress
response to starvation
prepulse inhibition
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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