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Invitrogen
Adenylate Cyclase 5/6 Polyclonal Antibody
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FIGURE: 1 / 5
Adenylate Cyclase 5/6 Antibody (PA5-75274) in IHC (P)
Immunohistochemistry analysis of Adenylate Cyclase 5/6 in paraffin-embedded human stomach carcinoma tissue (membrane and cytoplasmic staining) and negative control (right, with PBS only). Samples were incubated with Adenylate Cyclase 5/6 polyclonal antibody (Product # PA5-75274) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-75274
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 1111-1160 of Human ADCY 5
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Adenylate cyclase 5/6 encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A cyclase V; A cyclase VI; adenylate cyclase type V; adenylate cyclase type VI; adenylyl cyclase 5; adenylyl cyclase 6; adenylyl cyclase type V; ATP pyrophosphate-lyase 5; ATP pyrophosphate-lyase 6; ca(2+)-inhibitable adenylyl cyclase; epididymis secretory sperm binding protein; KIAA0422; unnamed protein product
Gene Aliases: AC5; AC6; ACVI; ADCYB; DSKOD; FDFM; LCCS8; mKIAA0422
UniProt ID: (Human) O95622, (Human) O43306, (Rat) Q04400, (Mouse) P84309, (Rat) Q03343
Entrez Gene ID: (Human) 111, (Human) 112, (Rat) 64532, (Mouse) 224129, (Mouse) 11512, (Rat) 25289
system process
renal water homeostasis
cAMP biosynthetic process
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cyclic nucleotide biosynthetic process
intracellular signal transduction
regulation of insulin secretion involved in cellular response to glucose stimulus
cellular response to glucagon stimulus
vascular endothelial cell response to laminar fluid shear stress
cellular response to forskolin
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-activating serotonin receptor signaling pathway
negative regulation of neuron projection development
negative regulation of urine volume
cellular response to prostaglandin E stimulus
cellular response to catecholamine stimulus
maintenance of protein location in plasma membrane
regulation of blood vessel diameter
cellular response to vasopressin
circadian rhythm
adenosine receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
heart development
locomotory behavior
neuromuscular process controlling balance
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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