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Invitrogen

DJ-1 Polyclonal Antibody

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DJ-1 Polyclonal Antibody

Product Details

PA5-78362

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:20,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Park7/DJ-1. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Amount

20 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735723

Product Specific Information

Positive Control: 293T, A431, HeLa, HepG2, U87-MG, SK-N-SH, IMR32, SK-N-AS, mouse pancreas, rat pancreas

Predicted Reactivity: Pig (100%), Chicken (100%), Bovine (100%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CAP1; contraception-associated protein 1; CTA-215D11.1; DJ-1 protein; early onset 7; epididymis secretory sperm binding protein Li 67p; fertility protein SP22; FLJ27376; FLJ34360; FLJ92274; maillard deglycase; oncogene DJ1; oncogene Dj1; Parkinson disease protein 7; OTTHUMP00000001350; OTTHUMP00000001351; PARK7 GENE; PARK7/DJ1; Parkinson disease (autosomal recessive, early onset) 7; parkinson disease protein 7 homolog; parkinson protein 7; parkinsonism-associated deglycase; protein deglycase DJ-1; protein deglycase DJ-1zDJ-1; protein DJ-1; protein DJ-1zDJ-1; protein/nucleic acid deglycase DJ-1; RNA-binding protein regulatory subunit; unnamed protein product; zDJ-1

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Gene Aliases: CAP1; DJ-1; DJ1; GATD2; HEL-S-67p; SP22; zgc:103725

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UniProt ID: (Human) Q99497, (Mouse) Q99LX0, (Rat) O88767, (Zebrafish) Q5XJ36

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Entrez Gene ID: (Human) 11315, (Mouse) 57320, (Rat) 117287, (Zebrafish) 449674

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Function(s)
core promoter sequence-specific DNA binding double-stranded DNA binding single-stranded DNA binding transcription coactivator activity mRNA binding receptor binding copper ion binding protein binding enzyme activator activity peptidase activity superoxide dismutase copper chaperone activity oxidoreductase activity, acting on peroxide as acceptor oxygen sensor activity enzyme binding kinase binding cytokine binding peptidase inhibitor activity receptor activator activity tyrosine 3-monooxygenase activator activity L-dopa decarboxylase activator activity protein deglycase activity identical protein binding protein homodimerization activity small protein activating enzyme binding ubiquitin-like protein conjugating enzyme binding cadherin binding mercury ion binding androgen receptor binding peroxiredoxin activity ubiquitin-protein transferase inhibitor activity scaffold protein binding DNA-binding transcription factor binding cupric ion binding cuprous ion binding ubiquitin-specific protease binding glyoxalase (glycolic acid-forming) activity RNA binding hydrolase activity
Process(es)
synaptic transmission, dopaminergic positive regulation of acute inflammatory response to antigenic stimulus DNA repair response to oxidative stress mitochondrion organization adult locomotory behavior methylglyoxal metabolic process detoxification of copper ion positive regulation of gene expression negative regulation of gene expression negative regulation of smooth muscle cell migration lactate biosynthetic process removal of superoxide radicals insulin secretion protein repair androgen receptor signaling pathway positive regulation of protein complex assembly negative regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of interleukin-8 production negative regulation of protein sumoylation cellular response to stress positive regulation of NAD(P)H oxidase activity cellular response to oxidative stress cellular response to reactive oxygen species cellular response to glyoxal negative regulation of protein catabolic process response to hydrogen peroxide glucose homeostasis hydrogen peroxide metabolic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter glycolate biosynthetic process negative regulation of protein export from nucleus regulation of inflammatory response detoxification of mercury ion protein stabilization dopamine uptake involved in synaptic transmission regulation of mitochondrial membrane potential positive regulation of protein kinase B signaling membrane depolarization membrane hyperpolarization regulation of androgen receptor signaling pathway detoxification of hydrogen peroxide cellular response to hydrogen peroxide detection of oxidative stress guanine deglycation guanine deglycation, glyoxal removal cellular detoxification of aldehyde cellular detoxification of methylglyoxal positive regulation of protein localization to nucleus regulation of synaptic vesicle endocytosis cellular response to oxygen-containing compound negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of mitochondrial electron transport, NADH to ubiquinone negative regulation of death-inducing signaling complex assembly negative regulation of protein K48-linked deubiquitination negative regulation of TRAIL-activated apoptotic signaling pathway positive regulation of dopamine biosynthetic process glyoxal metabolic process glyoxal catabolic process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway negative regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species biosynthetic process negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of vascular smooth muscle cell proliferation negative regulation of NMDA glutamate receptor activity negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway positive regulation of fertilization positive regulation of oxidative phosphorylation uncoupler activity positive regulation of reactive oxygen species metabolic process negative regulation of extrinsic apoptotic signaling pathway proteolysis protein deglycosylation autophagy inflammatory response single fertilization protein deglycation, glyoxal removal protein deglycation, methylglyoxal removal negative regulation of cell death guanine deglycation, methylglyoxal removal spermatogenesis response to xenobiotic stimulus fertilization regulation of TRAIL production maternal process involved in female pregnancy cellular response to lipopolysaccharide cellular response to hypoxia Ras protein signal transduction response to testosterone regulation of fibril organization positive regulation of mitophagy
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