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Invitrogen

mGluR5 Polyclonal Antibody

View all (33) mGluR5 antibodies

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Product Details

PA5-78623

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the Intracellular domain of mouse mGluR5. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.64 mg/mL

Amount

164 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2736147

Product Specific Information

Positive Control: mouse brain, rat brain

Predicted Reactivity: Human (81%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A830007B11Rik; D16Ium24; D16Ium24e; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member E; Glur-5; Glur5; Glurbeta1; glutamate receptor; glutamate receptor, metabotropic 5; GPRC1A; GRM 1; GRM 5; GRM1; GRM1 alpha; GRM1A; metabotropic 1; metabotropic glutamate receptor (mGluR5); metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; MGC25101; mGlu1; mGluR; mGluR1; mGluR1 alpha; mGluR1A; mGluR5; mGluR5a; unnamed protein product; variant b of mGluR5

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Gene Aliases: 6430542K11Rik; Glu5R; Gprc1e; mGluR5; mGluR5b

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UniProt ID: (Rat) P31424, (Mouse) Q3UVX5

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Entrez Gene ID: (Rat) 24418, (Mouse) 108071

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Function(s)
PLC activating G-protein coupled glutamate receptor activity adenylate cyclase inhibiting G-protein coupled glutamate receptor activity G-protein coupled receptor activity protein binding calmodulin binding glutamate receptor activity PDZ domain binding protein tyrosine kinase activator activity A2A adenosine receptor binding identical protein binding G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential protein tyrosine kinase binding
Process(es)
temperature homeostasis response to amphetamine desensitization of G-protein coupled receptor protein signaling pathway regulation of transcription, DNA-templated protein phosphorylation G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration phospholipase C-activating G-protein coupled glutamate receptor signaling pathway G-protein coupled glutamate receptor signaling pathway chemical synaptic transmission learning or memory learning locomotory behavior associative learning positive regulation of dopamine secretion operant conditioning protein targeting to nuclear inner membrane response to morphine positive regulation of MAPK cascade response to ethanol response to antibiotic phosphatidylinositol-mediated signaling regulation of long-term neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity modulation of synaptic transmission synapse organization positive regulation of calcium-mediated signaling cognition response to corticosterone regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential negative regulation of dendritic spine morphogenesis sensory perception of hot stimulus negative regulation of excitatory postsynaptic potential positive regulation of cellular response to hypoxia regulation of long term synaptic depression positive regulation of intracellular signal transduction positive regulation of sensory perception of pain cellular response to beta-amyloid conditioned place preference positive regulation of neural precursor cell proliferation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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