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Invitrogen
Caspase 6 p18 Polyclonal Antibody
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FIGURE: 1 / 4
Caspase 6 p18 Antibody (PA5-78922) in IHC (P)
Immunohistochemical analysis of Caspase-6 (P18) in a paraffin-embedded section of human colorectal adenocarcinoma tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution).The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2 μg/mL rabbit anti-Caspase-6 (P18) antibody (Product # PA5-78922) overnight at 4°C. Peroxidase... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-78922
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-6 (P18) (24-44aa AFYKREMFDPAEKYKMDHRRR).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Jurkat whole cell. IHC: human colorectal adenocarcinoma tissue, human pancreatic cancer tissue. Flow: SiHa cell.
Target Information
Caspase 6 is an enzyme that in humans is encoded by the caspase 6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Using radiation hybrid mapping, the Caspase 6 gene is localized to human chromosome 4q25-q26. Caspase 6 functions as a downstream enzyme in the caspase activation cascade. And Caspase 6 can cleave lamin A to its signature apoptotic fragment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptotic protease MCH-2; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; mammalian Ced-3 homologue 2
Gene Aliases: caspase-6; CSP-6; MCH2
UniProt ID: (Human) P55212
Entrez Gene ID: (Human) 839
activation of innate immune response
proteolysis
apoptotic process
protein autoprocessing
epithelial cell differentiation
positive regulation of apoptotic process
regulation of programmed cell death
positive regulation of neuron apoptotic process
protein maturation
positive regulation of necroptotic process
pyroptosis
intrinsic apoptotic signaling pathway by p53 class mediator
cellular response to staurosporine
hepatocyte apoptotic process
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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