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Invitrogen
Caspase 6 p18 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-78923
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of rat Caspase-6 (P18) (7-27aa FYRSREVLDPAEQYKMDHKRR).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Liver Tissue, Rat Kidney Tissue, Rat Testis Tissue, NRK Cell, Mouse Liver Tissue, Mouse Kidney Tissue, Mouse Testis Tissue. IHC: Rat Spleen Tissue, Rat Intestine Tissue, Mouse Lung Tissue IHC-F: Rat Spleen Tissue.
Target Information
Caspase 6 is an enzyme that in humans is encoded by the caspase 6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Using radiation hybrid mapping, the Caspase 6 gene is localized to human chromosome 4q25-q26. Caspase 6 functions as a downstream enzyme in the caspase activation cascade. And Caspase 6 can cleave lamin A to its signature apoptotic fragment.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptotic protease Mch-2; CASP-6; unnamed protein product
Gene Aliases: CASP-6; Mch2
UniProt ID: (Mouse) O08738
Entrez Gene ID: (Mouse) 12368, (Rat) 83584
activation of innate immune response
acute inflammatory response to non-antigenic stimulus
proteolysis
apoptotic process
axonal fasciculation
response to glucose
response to iron ion
protein autoprocessing
epithelial cell differentiation
response to cytokine
response to hydrogen peroxide
regulation of apoptotic process
positive regulation of apoptotic process
regulation of programmed cell death
positive regulation of neuron apoptotic process
positive regulation of retinal cell programmed cell death
positive regulation of necroptotic process
pyroptosis
intrinsic apoptotic signaling pathway by p53 class mediator
cellular response to staurosporine
positive regulation of release of cytochrome c from mitochondria
hepatocyte apoptotic process
lens development in camera-type eye
response to toxic substance
response to metal ion
response to ionizing radiation
response to gamma radiation
response to estradiol
response to testosterone
animal organ development
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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