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Invitrogen
Catenin alpha-1 Polyclonal Antibody, DyLight™ 488
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FIGURE: 1 / 1
Catenin alpha-1 Antibody (PA5-79091) in Flow
Flow Cytometry of Catenin alpha-1 in HeLa cells (blue line), isotype control rabbit IgG (green line) and unlabeled (red line). Samples were blocked with 10% goat serum and then incubated with Catenin alpha-1 Polyclonal Antibody, DyLight™ 488 (Product # PA5-79091) at a dilution of 1 μg (per 1x10^6 cells) for 30 min at 20°C.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79091
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292).
Conjugate
DyLight™ 488
DyLight™ 488
DyLight™ 488
Excitation/Emission Max
492/519 nm
View spectra
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control - Flow: Hela cell.
Target Information
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-E-catenin; cadherin-associated protein; catenin (cadherin-associated protein), alpha 1, 102kDa; epididymis secretory sperm binding protein; renal carcinoma antigen NY-REN-13; unnamed protein product
Gene Aliases: CAP102; MDBS2; MDPT2
UniProt ID: (Human) P35221
Entrez Gene ID: (Human) 1495
ovarian follicle development
cell adhesion
male gonad development
gap junction assembly
cell migration
axon regeneration
odontogenesis of dentin-containing tooth
apical junction assembly
response to estrogen
cellular response to indole-3-methanol
cell-cell adhesion
negative regulation of protein localization to nucleus
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