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Invitrogen
GSTA1/A2/A3/A4/A5 Polyclonal Antibody
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FIGURE: 1 / 4
GSTA1/A2/A3/A4/A5 Antibody (PA5-79335) in IHC (P)
Immunohistochemical analysis of GSTA1/A2/A3/A4/A5 in paraffin-embedded section of human liver cancer tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/mL rabbit anti-GSTA1/A2/A3/A4/A5 antibody (Product # PA5-79335) overnight at 4°C. Biotinyl... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79335
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived human GSTA1/A2/A3/A4/A5 recombinant protein (Position: A2-F222).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HepG2 whole cell, human HCCT tissue, human HCCP tissue, human HUH-7 whole cell, rat liver tissue, rat RH35 whole cell, mouse liver tissue. IHC: human lung cancer tissue, human liver cancer tissue, human liver cancer tissue.
Target Information
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver (hepatocytes) and kidney (proximal tubules). In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity, thereby protecting the cells from reactive oxygen species and the products of peroxidation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 13-hydroperoxyoctadecadienoate peroxidase; androst-5-ene-3,17-dione isomerase; detoxification enzyme; GHS transferase; glutathione S-alkyltransferase A1; glutathione S-alkyltransferase A2; glutathione S-alkyltransferase A3; glutathione S-alkyltransferase A4; glutathione S-aralkyltransferase A2; glutathione S-aralkyltransferase A3; glutathione S-aralkyltransferase A4; glutathione S-aryltransferase A1; glutathione S-aryltransferase A2; glutathione S-aryltransferase A3; glutathione S-aryltransferase A4; glutathione S-transferase; glutathione S-transferase (GST, EC 2.5.1.18); glutathione S-transferase 2; glutathione S-transferase 5.7; glutathione S-transferase A1; glutathione S-transferase A2; glutathione S-transferase A3; glutathione S-transferase A3 subunit; glutathione S-transferase A3-3; glutathione S-transferase A4; glutathione S-transferase A4-4; glutathione S-transferase A5; glutathione S-transferase A5-5; glutathione S-transferase GT41A; glutathione S-transferase Ha subunit 1; glutathione S-transferase Ha subunit 1 (EC 2.5.1.18); glutathione S-transferase Ha subunit 2 (EC 2.5.1.18); glutathione S-transferase Ya; glutathione S-transferase Ya subunit; glutathione S-transferase Ya-1; glutathione S-transferase Ya-2; glutathione S-transferase Ya1; glutathione S-transferase Ya3; glutathione S-transferase Yc; glutathione S-transferase Yc subunit; glutathione S-transferase Yc1 subunit; glutathione S-transferase Yc2 subunit; glutathione S-transferase Yk; glutathione transferase; glutathione transferase (EC 2.5.1.18); glutathione transferase A4-4; glutathione transferase YA subunit; Glutathione-S-transferase alpha type (Ya); glutathione-S-transferase, alpha type2; gluthione S-transferase subunit 1 (GST,EC 2.5.1.18); GST 1-1; GST 1a-1a; GST 1b-1b; GST 8-8; GST A1-1; GST A2-2; GST A4-4; GST A5-5; GST class-alpha member 1; GST class-alpha member 2; GST class-alpha member 3; GST class-alpha member 4; GST class-alpha member 5; GST HA subunit 1; GST HA subunit 2; GST K; GST Ya1; GST Ya2; GST Yc2; GST Yk; GST-gamma; GSTA1; GSTA4-4; ligandin; liver GST2; S-(hydroxyalkyl)glutathione lyase A1; S-(hydroxyalkyl)glutathione lyase A2; S-(hydroxyalkyl)glutathione lyase A3; S-(hydroxyalkyl)glutathione lyase A4; testicular tissue protein Li 80; testis tissue sperm-binding protein Li 59n; unnamed protein product
Gene Aliases: Gm10639; GST 2-2; GST A3-3; GST AA; GST B; GST Yc1; GST-epsilon; GST2; Gst2-1; Gst2-2; Gst2-3; GST5.7; Gsta1; GSTA1-1; Gsta2; GSTA2-2; Gsta3; GSTA3-3; GSTA4-4; Gsta5; Gstc-2; Gstc2; GTA2; GTA3; GTA4; GTH1; GTH2; mGsta4; Yc1; Yc2
glutathione transferase activity
glutathione peroxidase activity
steroid delta-isomerase activity
fatty acid binding
protein binding
phospholipid-hydroperoxide glutathione peroxidase activity
molecular carrier activity
identical protein binding
protein homodimerization activity
dinitrosyl-iron complex binding
glutathione binding
toxic substance binding
glutathione metabolic process
xenobiotic metabolic process
response to bacterium
epithelial cell differentiation
response to stilbenoid
xenobiotic catabolic process
response to caloric restriction
cellular oxidant detoxification
ureteric bud development
aflatoxin catabolic process
prostaglandin metabolic process
heme catabolic process
linoleic acid metabolic process
glutathione derivative biosynthetic process
response to xenobiotic stimulus
response to nutrient levels
response to herbicide
response to zinc ion
response to nicotine
cellular response to lithium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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