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Invitrogen

ICAM-1 (CD54) Polyclonal Antibody

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ICAM-1 (CD54) Polyclonal Antibody

Product Details

PA5-79427

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-

ELISA (ELISA)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived human ICAM1 recombinant protein (Position: Q28-R268).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746543

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat spleen tissue, rat thymus tissue, rat RH35 cell, mouse spleen tissue, mouse thymus tissue, mouse HEPA1-6 cell, mouse heart tissue, human Raji whole cell, human K562 whole cell, human HepG2 whole cell, human 293T whole cell. IHC: human lung cancer tissue, human bladder urothelial carcinoma tissue, human colorectal adenocarcinoma tissue, human placenta tissue, human spleen tissue. ICC/IF: A431 cell. Flow: PC-3 cell.

Target Information

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cell surface glycoprotein P3.58; epididymis secretory sperm binding protein; Human rhinovirus receptor; ICAM-1; ICAM-1 soluble variant; Icam1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule-1 precursor; Ly 47; major group rhinovirus receptor; major group rhinovirus receptor precusor; MALA2; myD10; sCD54; soluble CD54; Surface antigen of activated B cells; unnamed protein product

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Gene Aliases: BB2; CD54; ICAM; Icam-1; Ly-47; MALA-2; P3.58; RICAM-I

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UniProt ID: (Human) P05362, (Rat) Q00238, (Mouse) P13597

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Entrez Gene ID: (Human) 3383, (Rat) 25464, (Mouse) 15894

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Function(s)
transmembrane signaling receptor activity integrin binding protein binding signaling receptor activity receptor agonist activity macromolecular complex binding
Process(es)
ovarian follicle development response to hypoxia response to amphetamine T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell acute inflammatory response to antigenic stimulus T cell antigen processing and presentation positive regulation of cellular extravasation immune response cell adhesion leukocyte cell-cell adhesion I-kappaB kinase/NF-kappaB signaling regulation of cell shape response to xenobiotic stimulus response to ionizing radiation response to sulfur dioxide membrane to membrane docking positive regulation of actin filament polymerization cellular response to nutrient levels response to lipopolysaccharide response to insulin cell adhesion mediated by integrin cell-cell adhesion mediated by integrin response to gonadotropin response to amino acid positive regulation of GTPase activity positive regulation of nitric oxide biosynthetic process response to ethanol positive regulation of vasoconstriction regulation of activated T cell proliferation response to copper ion positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration negative regulation of calcium ion transport establishment of endothelial barrier leukocyte adhesion to vascular endothelial cell positive regulation of T cell apoptotic process positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to alkaloid cellular response to glucose stimulus cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to hypoxia cellular response to dexamethasone stimulus T cell extravasation cellular senescence establishment of endothelial intestinal barrier establishment of Sertoli cell barrier cell-cell adhesion regulation of ruffle assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine cellular response to beta-amyloid positive regulation of leukocyte adhesion to vascular endothelial cell cellular response to leukemia inhibitory factor negative regulation of endothelial cell apoptotic process regulation of leukocyte mediated cytotoxicity immune effector process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules signal transduction adhesion of symbiont to host receptor-mediated virion attachment to host cell cellular response to oxygen-containing compound
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