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Invitrogen
IL-7 Polyclonal Antibody
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FIGURE: 1 / 3
IL-7 Antibody (PA5-79510) in IHC (P)
Immunohistochemical analysis of IL7 in a paraffin-embedded section of mouse lymph node tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution).The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2 μg/mL rabbit anti-IL7 antibody (Product # PA5-79510) overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as sec... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79510
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived mouse IL7 recombinant protein (Position: E26-I154).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: mouse brain tissue, mouse thymus tissue, NIH3T3 whole cell. IHC: mouse lymph nodes tissue, rat lymph nodes tissue.
Target Information
Interleukin 7 (IL-7) is a hematopoietic cytokine that is constitutively produced by stromal cells from the bone marrow and thymus. IL-7 signals through the IL-7R to promote the differentiation of hematopoietic stem cells to lymphoid precursor cells, which give rise to T cells, B cells, and natural killer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H-IL-7; IL-7; IL-7 receptor alpha chain; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; ILN; Interleukin; interleukin 7 receptor alpha chain; interleukin-7 receptor precursor; Interleukin7; M-IL-7; unnamed protein product
Gene Aliases: A630026I06Rik; CD127; hlb368; Il-7; IL-7Ralpha
UniProt ID: (Mouse) P10168, (Mouse) P16872
Entrez Gene ID: (Rat) 25647, (Mouse) 16196, (Rat) 294797, (Mouse) 16197
positive regulation of cytokine-mediated signaling pathway
T cell lineage commitment
immune response
response to X-ray
regulation of gene expression
positive regulation of gene expression
cytokine-mediated signaling pathway
positive regulation of B cell proliferation
positive regulation of chemokine production
interleukin-7-mediated signaling pathway
negative regulation of apoptotic process
negative regulation of catalytic activity
bone resorption
positive regulation of B cell differentiation
positive regulation of T cell differentiation
positive regulation of organ growth
homeostasis of number of cells within a tissue
regulation of peptidyl-tyrosine phosphorylation
cellular response to hypoxia
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
cell morphogenesis
negative regulation of T cell mediated cytotoxicity
biological_process
positive regulation of cell proliferation
regulation of cell size
cellular homeostasis
hemopoiesis
T cell differentiation
positive regulation of T cell differentiation in thymus
B cell proliferation
positive regulation of JAK-STAT cascade
lymph node development
homeostasis of number of cells
defense response to Gram-positive bacterium
negative regulation of T cell apoptotic process
positive regulation of STAT cascade
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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