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Invitrogen
NOX1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79751
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human NOX1 (354-374aa, HIRAAGDWTENLIRAFEQQYS).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.01mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: HELA whole cell, MCF-7 whole cell. IHC: Human Lung Cancer Tissue.
Target Information
Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv. NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H (+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 have the potential to be effective treatments for a range of ischemic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); mitogenic oxidase 1; Mox1; similar to gp91phox; NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase homolog-1; NOH-1L; NOH-1Lv; NOH-1S; NOX1; unnamed protein product
Gene Aliases: GP91-2; MOX1; NOH-1; NOH-1L; NOH1
UniProt ID: (Human) Q9Y5S8
Entrez Gene ID: (Human) 27035
angiogenesis
NADP metabolic process
defense response
inflammatory response
signal transduction
regulation of blood pressure
positive regulation of cell proliferation
positive regulation of vascular endothelial growth factor production
cell migration
superoxide anion generation
hydrogen peroxide metabolic process
positive regulation of integrin biosynthetic process
respiratory burst
positive regulation of smooth muscle cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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