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Invitrogen

SOX10 Polyclonal Antibody

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SOX10 Polyclonal Antibody

Product Details

PA5-80053

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-5 µg/mL
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence of human SOX10 (KPHIDFGNVDIGEISHEVMSNMETFDVAELDQYL).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2747168

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human SH-SY5Y whole cell, human U251 whole cell, human U2OS whole cell, human U87 whole cell, rat brain tissue, rat C6 whole cell, mouse brain tissue, mouse Neuro-2a whole cellIHC: human melanoma tissue, mouse brain tissue.

Target Information

SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dominant megacolon; dominant megacolon, mouse, human homolog of; MGC15649; SOX10; SRY; SRY (sex determining region Y)-box 10; SRY box 10; SRY-box 10; SRY-box containing gene 10; SRY-related HMG-box gene 10; transcription factor SOX-M; unnamed protein product

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Gene Aliases: DOM; gt; PCWH; SOX-10; Sox21; WS2E; WS4; WS4C

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UniProt ID: (Human) P56693, (Mouse) Q04888, (Rat) O55170

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Entrez Gene ID: (Human) 6663, (Mouse) 20665, (Rat) 29361

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding identical protein binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development neural crest cell migration morphogenesis of an epithelium positive regulation of neuroblast proliferation regulation of transcription, DNA-templated transcription elongation from RNA polymerase II promoter peripheral nervous system development negative regulation of Schwann cell proliferation positive regulation of gene expression oligodendrocyte development positive regulation of gliogenesis neural crest cell development central nervous system myelination cell differentiation melanocyte differentiation positive regulation of myelination lacrimal gland development negative regulation of apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell maturation enteric nervous system development digestive tract morphogenesis developmental growth oligodendrocyte differentiation stem cell differentiation morphogenesis of a branching epithelium cellular response to progesterone stimulus cellular response to xenobiotic stimulus negative regulation of canonical Wnt signaling pathway developmental process cell development regulation of transcription from RNA polymerase II promoter anatomical structure morphogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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