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Invitrogen
TET1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-81065
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the C-terminus of the Human TET1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human TET1.
Target Information
Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CXXC finger 6; CXXC zinc finger 6; CXXC-type zinc finger protein 6; LCX; leukemia-associated protein with a CXXC domain; RP11-119F7.1; ten-eleven translocation 1 gene protein; ten-eleven translocation-1; tet oncogene 1
Gene Aliases: bA119F7.1; CXXC6; LCX
UniProt ID: (Human) Q8NFU7
Entrez Gene ID: (Human) 80312
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
iron ion binding
protein binding
zinc ion binding
methyl-CpG binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
methylcytosine dioxygenase activity
negative regulation of transcription from RNA polymerase II promoter
inner cell mass cell differentiation
chromatin remodeling
protein O-linked glycosylation
regulation of gene expression
stem cell population maintenance
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
cellular response to reactive oxygen species
regulation of gene expression, epigenetic
hypomethylation of CpG island
positive regulation of transcription from RNA polymerase II promoter
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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