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Invitrogen
PCSK9 Polyclonal Antibody
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FIGURE: 1 / 3
PCSK9 Antibody (PA5-81454) in ICC/IF
Immunofluorescence staining of PCSK9 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with PCSK9 Polyclonal Antibody (Product # PA5-81454, 1:1,000) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-81454
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Mouse PCSK9/NARC1 Protein (Met1-Gln694)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Mouse PCSK9/NARC1.
Target Information
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: convertase subtilisin; hypercholesterolemia; NARC-1; neural apoptosis regulated convertase 1; OTTHUMP00000009833; proprotein convertase 9; proprotein convertase PC9; protease; kexin 9; PCSK9; proprotein; subtilisin/kexin-like protease PC9; unnamed protein product
Gene Aliases: FH3; HCHOLA3; Narc1; PC9
UniProt ID: (Mouse) Q80W65
Entrez Gene ID: (Mouse) 100102
endopeptidase activity
serine-type endopeptidase activity
serine-type peptidase activity
sodium channel inhibitor activity
low-density lipoprotein particle binding
receptor inhibitor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding
transporter inhibitor activity
kidney development
liver development
negative regulation of receptor recycling
negative regulation of receptor internalization
positive regulation of receptor internalization
proteolysis
triglyceride metabolic process
phospholipid metabolic process
lysosomal transport
cholesterol metabolic process
cellular response to starvation
negative regulation of low-density lipoprotein particle clearance
protein processing
protein autoprocessing
neurogenesis
neuron differentiation
low-density lipoprotein receptor particle metabolic process
low-density lipoprotein particle receptor catabolic process
regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
lipoprotein metabolic process
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of sodium ion import across plasma membrane
negative regulation of receptor-mediated endocytosis involved in cholesterol transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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