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Invitrogen
HBB Polyclonal Antibody
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FIGURE: 1 / 3
HBB Antibody (PA5-85432) in WB
Western Blot using HBB Polyclonal Antibody (Product # PA5-85432). Untreated (–) and treated (+) mouse tissue extracts (30 µg) were separated by 15% SDS-PAGE, and the membrane was blotted with HBB Polyclonal Antibody (Product # PA5-85432) diluted at 1:500. (CFA: Complete Freunds adjuvant).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-85432
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human Hemoglobin beta Recombinant protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Rat (81%), Pig (85%), Sheep (81%), Rhesus Monkey (94%), Bovine (84%).
Positive Control: human plasma, Mouse Leukocyte, mouse leukocyte treated with CFA, rat spleen.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon-gamma-G-gamma-A-delta-beta-3'.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta globin; beta globin chain; beta-1-globin; Hb Monza protein; HBB; hemoglobin; hemoglobin beta; hemoglobin beta chain complex; hemoglobin beta chain, major-form; hemoglobin beta subunit; hemoglobin beta-1 chain; hemoglobin subunit beta; hemoglobin, beta; III beta-1 globin; III beta-2 globin; major beta-hemoglobin; sickle beta-hemoglobin; unnamed protein product; unstable hemoglobin; hemoglobin 'Louisville'
Gene Aliases: beta-globin; CD113t-C; ECYT6; Hbb
UniProt ID: (Human) P68871, (Rat) P02091
Entrez Gene ID: (Human) 3043, (Rat) 24440
inflammatory response
carbon dioxide transport
oxygen transport
nitric oxide transport
response to hydrogen peroxide
hydrogen peroxide catabolic process
positive regulation of nitric oxide biosynthetic process
erythrocyte development
renal absorption
platelet aggregation
cellular oxidant detoxification
glutathione metabolic process
regulation of eIF2 alpha phosphorylation by heme
hemopoiesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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