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Invitrogen

Huntingtin Polyclonal Antibody

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View all (41) Huntingtin antibodies

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Huntingtin Polyclonal Antibody

Product Details

PA5-85721

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Huntingtin. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.4 mg/mL

Amount

140 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792860

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Sheep (100%).

Positive Control: U87-MG.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HD protein homolog; huntingtin (Huntington disease); Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; Huntington gene; unnamed protein product

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Gene Aliases: C430023I11Rik; HD; Hdh; IT15; LOMARS

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UniProt ID: (Human) P42858

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Entrez Gene ID: (Human) 3064, (Rat) 29424, (Mouse) 15194

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Function(s)
p53 binding phosphoprotein phosphatase activity protein binding profilin binding kinase binding heat shock protein binding dynactin binding identical protein binding ion channel binding dynein intermediate chain binding beta-tubulin binding receptor binding diazepam binding
Process(es)
urea cycle establishment of mitotic spindle orientation mitochondrial transport ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER mitochondrion organization microtubule-based process microtubule depolymerization endoplasmic reticulum organization Golgi organization dopamine receptor signaling pathway spermatogenesis gastrulation central nervous system development brain development learning or memory learning grooming behavior locomotory behavior axo-dendritic transport associative learning determination of adult lifespan visual learning anatomical structure morphogenesis anterior/posterior pattern specification regulation of signal transduction gene expression regulation of gene expression endosomal transport lactate biosynthetic process from pyruvate quinolinate biosynthetic process striatum development olfactory lobe development neural plate formation neurogenesis peptide hormone secretion insulin secretion protein destabilization protein localization to nucleus social behavior vocal learning hormone metabolic process positive regulation of apoptotic process negative regulation of apoptotic process regulation of neuron apoptotic process positive regulation of cilium assembly vesicle transport along microtubule regulation of synaptic plasticity paraxial mesoderm formation synaptic vesicle transport neuron development positive regulation of calcium-mediated signaling mRNA transport response to calcium ion multicellular organismal iron ion homeostasis protein localization to centrosome cellular senescence postsynapse to nucleus signaling pathway regulation of protein localization to nucleus positive regulation of mitophagy positive regulation of nonmotile primary cilium assembly positive regulation of lipophagy regulation of intracellular mRNA localization regulation of CAMKK-AMPK signaling cascade positive regulation of CAMKK-AMPK signaling cascade positive regulation of aggrephagy positive regulation of motile cilium assembly negative regulation of extrinsic apoptotic signaling pathway
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