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Invitrogen

Aurora A Polyclonal Antibody

View all (49) Aurora A antibodies

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Aurora A Polyclonal Antibody

Product Details

PA5-86309

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to amino acids 251-300 of Human AURKA.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803092

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AURAK; aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; aurora-A; aurora-related kinase 1; aurora/IP; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; AURORA2; breast tumor-amplified kinase; EC 2.7.11.1; hARK1; IAK1; ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; protein kinase; protein phosphatase 1, regulatory subunit 47; ratAurA; RP5-1167H4.6; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; serine/threonine-protein kinase Ayk1; STK6; aurora-A; IPL1-related kinase; AIK; BTAK; STK15; unnamed protein product

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Gene Aliases: AIK; AIRK1; ARK-1; ARK1; AURA; Aurora-A; Ayk1; BTAK; IAK; IAK1; PPP1R47; STK15; STK6; STK7

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UniProt ID: (Human) O14965, (Mouse) P97477

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Entrez Gene ID: (Human) 6790, (Rat) 261730, (Mouse) 20878

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding protein kinase binding protein heterodimerization activity protein serine kinase activity molecular function activator activity ubiquitin protein ligase binding histone kinase activity (H3-S10 specific)
Process(es)
meiotic spindle organization microtubule cytoskeleton organization mitotic cell cycle chromatin remodeling protein phosphorylation spindle organization mitotic spindle organization spindle assembly involved in female meiosis I centrosome cycle mitotic centrosome separation response to wounding anterior/posterior axis specification negative regulation of gene expression peptidyl-serine phosphorylation regulation of protein stability response to estradiol positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of cytokinesis negative regulation of apoptotic process positive regulation of translation positive regulation of mitotic cell cycle meiotic cell cycle centrosome localization cilium disassembly protein localization to centrosome positive regulation of mitochondrial fission liver regeneration positive regulation of oocyte maturation positive regulation of meiotic cell cycle process involved in oocyte maturation neuron projection extension G2/M transition of mitotic cell cycle regulation of G2/M transition of mitotic cell cycle negative regulation of protein binding regulation of microtubule-based process cell cycle G2/M phase transition positive regulation of mitotic nuclear division regulation of centrosome cycle protein autophosphorylation positive regulation of cell cycle process regulation of signal transduction by p53 class mediator
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