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          • Primary Antibodies ›
          • FGFR1 Antibodies

          Invitrogen

          FGFR1 Polyclonal Antibody

          View all (60) FGFR1 antibodies

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          Cite FGFR1 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          FGFR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          FGFR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          FGFR1 Antibody (PA5-86349) in IHC (P)

          Immunohistochemical analysis of FGFR1 in paraffin-embedded human breast carcinoma tissue. Sample was incubated with FGFR1 polyclonal antibody (Product # PA5-86349) using a 1:100 dilution. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          FGFR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          FGFR1 Polyclonal Antibody

          Product Details

          PA5-86349

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide, corresponding to amino acids 731-780 of Human FGFR1.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.2, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2803131

          Product Specific Information

          Purity is > 95% by SDS-PAGE.

          Target Information

          FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: 2.7.10.1; basic fibroblast growth factor receptor 1; CD331 antigen; FGF Receptor; FGF receptor precursor; FGF receptor-1; FGF receptor-1 precursor; FGFR; fgfr 1; FGFR1-IIIb; receptor tyrosine kinase; FGFR1/PLAG1 fusion; fibroblast growth factor receptor (FGFr) transmembrane form; fibroblast growth factor receptor FGFR-1 secreted form; fibroblast growth factor-receptor precursor; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; orf 5' of fibroblast growth factor receptor 1 FGFR-1; proto-oncogene c-Fgr; soluble form; FGF-R1; unnamed protein product

          View more View less

          Gene Aliases: bFGF-R; bFGF-R-1; BFGFR; c-fgr; CD331; CEK; Eask; ECCL; FGFBR; FGFR-1; FGFR-I; FLG; FLT-2; FLT2; Fr1; HBGFR; HH2; HRTFDS; Hspy; KAL2; MFR; N-SAM; OGD

          View more View less

          UniProt ID: (Human) P11362, (Mouse) P16092, (Rat) Q04589

          View more View less

          Entrez Gene ID: (Human) 2260, (Mouse) 14182, (Rat) 79114

          View more View less

          Function(s)
          protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity protein binding ATP binding heparin binding fibroblast growth factor binding identical protein binding protein homodimerization activity receptor-receptor interaction receptor binding SH2 domain binding macromolecular complex binding cell adhesion molecule binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter angiogenesis ureteric bud development in utero embryonic development organ induction epithelial to mesenchymal transition positive regulation of mesenchymal cell proliferation chondrocyte differentiation regulation of mitotic cell cycle brain development salivary gland morphogenesis sensory perception of sound positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway gene expression regulation of gene expression regulation of cell cycle process negative regulation of gene expression positive regulation of cell communication positive regulation of fibroblast migration regulation of phosphate transport positive regulation of neuron projection development peptidyl-tyrosine phosphorylation stem cell population maintenance orbitofrontal cortex development postnatal olfactory bulb interneuron migration ventricular zone neuroblast division forebrain generation of neurons central nervous system neuron development tangential migration from the subventricular zone to the olfactory bulb positive regulation of signaling lung development embryonic limb morphogenesis epithelial cell differentiation midbrain development neuron projection development biomineral tissue development fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development regulation of cell proliferation inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration ear development cellular response to fibroblast growth factor stimulus positive regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation paraxial mesoderm development regulation of lateral mesodermal cell fate specification cell maturation blood vessel morphogenesis generation of neurons mesenchymal cell differentiation regulation of phosphorus metabolic process positive regulation of protein kinase B signaling calcium ion homeostasis positive regulation of cardiac muscle cell proliferation auditory receptor cell development branching involved in salivary gland morphogenesis lung-associated mesenchyme development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling vasculogenesis involved in coronary vascular morphogenesis vitamin D3 metabolic process diphosphate metabolic process cementum mineralization regulation of stem cell proliferation positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor production regulation of postsynaptic density assembly positive regulation of mitotic cell cycle DNA replication response to sodium phosphate positive regulation of vascular endothelial cell proliferation positive regulation of hepatic stellate cell activation positive regulation of parathyroid hormone secretion positive regulation of endothelial cell chemotaxis regulation of extrinsic apoptotic signaling pathway in absence of ligand response to ischemia female pregnancy response to nutrient levels cellular response to lipopolysaccharide cellular response to growth factor stimulus cellular response to histamine cellular response to nerve growth factor stimulus MAPK cascade skeletal system development neuron migration protein phosphorylation positive regulation of phospholipase activity cell migration chordate embryonic development regulation of cell differentiation phosphatidylinositol-mediated signaling skeletal system morphogenesis
          It has to be done as per old AB suggested Products section.

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