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Invitrogen

NGFR Polyclonal Antibody

View all (106) NGFR (CD271) antibodies

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NGFR Polyclonal Antibody

Product Details

PA5-86503

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, corresponding to amino acids 251-300 of Human NGFR p75.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803279

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD271 antigen; gp80-LNGFR; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; low-affinity nerve growth factor receptor p75NGFR; low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; NGFR; p-75; p75 ICD; p75 neurotrophin receptor; p75 ntr; TNFR superfamily, member 16; TNR16; unnamed protein product

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Gene Aliases: CD271; Gp80-LNGFR; LNGFR; p75; p75(NTR); p75NGFR; p75NTR; RNNGFRR; TNFRSF16

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UniProt ID: (Human) P08138, (Mouse) Q9Z0W1, (Rat) P07174

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Entrez Gene ID: (Human) 4804, (Mouse) 18053, (Rat) 24596

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Function(s)
beta-amyloid binding transmembrane signaling receptor activity death receptor activity protein binding calmodulin binding coreceptor activity small GTPase binding ubiquitin protein ligase binding signaling receptor activity neurotrophin binding nerve growth factor binding neurotrophin TRKA receptor binding identical protein binding macromolecular complex binding preprotein binding
Process(es)
cellular glucose homeostasis intracellular protein transport signal transduction Rho protein signal transduction axon guidance central nervous system development circadian rhythm regulation of gene expression positive regulation of neuron projection development negative regulation of neuron projection development detection of temperature stimulus negative regulation of angiogenesis nerve development negative regulation of cell migration hair follicle morphogenesis positive regulation of myelination positive regulation of synaptic transmission, cholinergic circadian regulation of gene expression cellular response to oxidative stress positive regulation of Rho protein signal transduction dorsal aorta development negative regulation of fibroblast growth factor receptor signaling pathway regulation of cell proliferation positive regulation of odontogenesis of dentin-containing tooth glucose homeostasis positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process skin development positive regulation of neuron differentiation positive regulation of fibroblast proliferation negative regulation of multicellular organismal process neuron apoptotic process negative regulation of hair follicle development positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization positive regulation of synaptic transmission, glutamatergic negative regulation of dendritic spine development extrinsic apoptotic signaling pathway presynaptic modulation of chemical synaptic transmission positive regulation of protein localization to nucleus positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis cellular response to beta-amyloid positive regulation of neural precursor cell proliferation positive regulation of endothelial cell apoptotic process regulation of reactive oxygen species metabolic process positive regulation of excitatory postsynaptic potential positive regulation of apoptotic signaling pathway spermatogenesis response to lipopolysaccharide skeletal muscle cell differentiation response to ethanol
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