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Invitrogen

IFN beta Polyclonal Antibody

View all (35) IFN beta antibodies

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Product Details

PA5-86768

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to residues in Human IFNB1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2803528

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: fibroblast interferon; IFN b; IFN β; IFN-beta; IFNbeta; IFNβ; Interferon; interferon 1da1; Interferon b; interferon beta 1, fibroblast; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1; unnamed protein product

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Gene Aliases: If1da1; IFB; IFF; IFN-beta; IFNB

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UniProt ID: (Human) P01574, (Mouse) P01575, (Rat) P70499

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Entrez Gene ID: (Human) 3456, (Mouse) 15977, (Rat) 24481

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Function(s)
cytokine activity cytokine receptor binding type I interferon receptor binding protein binding chloramphenicol O-acetyltransferase activity
Process(es)
adaptive immune response macrophage activation involved in immune response T cell activation involved in immune response B cell activation involved in immune response natural killer cell activation involved in immune response negative regulation of immunoglobulin production negative regulation of immune system process regulation of transcription from RNA polymerase II promoter defense response immune response humoral immune response signal transduction JAK-STAT cascade negative regulation of cell proliferation positive regulation of autophagy cytokine-mediated signaling pathway negative regulation of interferon-gamma production cellular response to interferon-beta B cell proliferation defense response to bacterium response to exogenous dsRNA negative regulation of viral genome replication innate immune response leukocyte activation negative regulation of T cell differentiation negative regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter negative regulation of multicellular organismal process defense response to virus type I interferon signaling pathway negative regulation of cell adhesion molecule production neuron cellular homeostasis cellular response to dsRNA cellular response to dexamethasone stimulus positive regulation of transforming growth factor beta production negative regulation of mononuclear cell migration receptor signaling pathway via STAT cellular response to virus negative regulation of Lewy body formation antiviral innate immune response negative regulation of neuroinflammatory response positive regulation of protein localization to nucleus negative regulation of matrix metallopeptidase secretion negative regulation of blood-brain barrier permeability negative regulation of T-helper 2 cell cytokine production positive regulation of apoptotic signaling pathway response to stress endoplasmic reticulum unfolded protein response cellular response to lipopolysaccharide cellular response to exogenous dsRNA cellular response to dsDNA cell surface receptor signaling pathway response to virus natural killer cell activation positive regulation of innate immune response regulation of MHC class I biosynthetic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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