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Invitrogen
GLT-1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-87522
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.18 mg/mL
Amount
18 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: MCF7, HepG2, SW480, Mouse liver, Rat liver; Cellular Location: Membrane, Multi-pass membrane protein
Immunogen sequence: LDRMRTSVNV VGDSFGAGIV YHLSKSELDT IDSQHRVHED IEMTKTQSIY DDMKNHRESN SNQCVYAAHN SVIVDECKVT LAANGKSADC SVEEEPWKRE K
Target Information
Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EAAT2 variant mEAAT2/5UT2; EAAT2 variant mEAAT2/5UT5; GLT1a; GLT1b; GLT1c; glutamate transporter 1c; mGLT-1; mGLT-1A; mGLT-1B; OTTHUMP00000165209; OTTHUMP00000165210; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1, member 2; unnamed protein product
Gene Aliases: 1700091C19Rik; 2900019G14Rik; Eaat2; GLT-1; GLT1; MGLT1
UniProt ID: (Mouse) P43006
Entrez Gene ID: (Mouse) 20511
glutathione biosynthetic process
nervous system development
visual behavior
response to xenobiotic stimulus
response to light stimulus
response to wounding
neutral amino acid transport
L-glutamate transport
telencephalon development
adult behavior
multicellular organism growth
response to amino acid
positive regulation of glucose import
protein homotrimerization
L-aspartate transmembrane transport
D-aspartate import
cellular response to cocaine
cellular response to hypoxia
anion transmembrane transport
L-glutamate import across plasma membrane
neurotransmitter reuptake
L-aspartate import across plasma membrane
cysteine transmembrane transport
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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