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Invitrogen
LYK5 Polyclonal Antibody
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Product Details
PA5-87821
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 25-210 of human STRADA (NP_6991662)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.98 mg/mL
Amount
198 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FLPEGGCYEL LTVIGKGFED LMTVNLARYK PTGEYVTVRR INLEACSNEM VTFLQGELHV SKLFNHPNIV PYRATFIADN ELWVVTSFMA YGSAKDLICT HFMDGMNELA IAYILQGVLK ALDYIHHMGY VHRSVKASHI LISVDGKVYL SGLRSNLSMI SHGQRQRVVH DFPKYSVKVL PWLSPE; Positive Samples: Mouse skeletal muscle; Cellular Location: Cytoplasm, Nucleus
Target Information
LYK5; STE20-related Adaptor Protein (STRAD); FLJ90524. Gene Map Locus is 17q23.3 and members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein kinase; protein kinase LYK5; putative serine/threonine kinase; serologically defined breast cancer antigen NY-BR-96; STE20-like pseudokinase; STE20-related adapter protein; STE20-related kinase adaptor alpha; STRAD alpha; unnamed protein product
Gene Aliases: 2610019A05Rik; 6030402H20Rik; E130112C09Rik; LYK5; NY-BR-96; PMSE; Stlk; STLK5; STRAD; STRAD alpha
UniProt ID: (Human) Q7RTN6, (Mouse) Q3UUJ4
Entrez Gene ID: (Human) 92335, (Mouse) 72149
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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