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Invitrogen
GRASP1 Polyclonal Antibody
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FIGURE: 1 / 1
GRASP1 Antibody (PA5-88318) in WB
Western blot analysis of GRASP1 in extracts of various cell lines. Samples were incubated with GRASP1 Polyclonal antibody (Product # PA5-88318) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-88318
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 642-841 of human GRIPAP1 (NP_0645223)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
5.06 mg/mL
Amount
506 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RSGLEELVLS EMNSPSRTQT GDSSSISSFS YREILREKES SAVPARSLSS SPQAQPPRPA ELSDEEVAEL FQRLAETQQE KWMLEEKVKH LEVSSASMAE DLCRKSAIIE TYVMDSRIDV SVAAGHTDRS GLGSVLRDLV KPGDENLREM NKKLQNMLEE QLTKNMHLHK DMEVLSQEIV RLSKECVGPP DPDLEPGETS; Positive Samples: U-87MG, Jurkat, HeLa, HepG2; Cellular Location: Early endosome
Target Information
PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo (Scannevin and Huganir, 2000). Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity (Ye et al., 2000).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GRIP-1; GRIP1; MPMGp800B12492Q3
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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