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Invitrogen
Neutrophil elastase Polyclonal Antibody
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FIGURE: 1 / 7
Neutrophil elastase Antibody (PA5-88916) in ICC/IF
Immunofluorescence analysis of Neutrophil elastase in mouse bone marrow cells. Samples were incubated with Neutrophil elastase Polyclonal antibody (Product # PA5-88916) using a dilution of 1:200 (40x lens). Blue: DAPI for nuclear staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-88916
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.5 mg/mL
Amount
250 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: LO2, Mouse brain
Immunogen sequence: IVGGRRARPH AWPFMVSLQL RGGHFCGATL IAPNFVMSAA HCVANVNVRA VRVVLGAHNL SRREPTRQVF AVQRIFENGY DPVNLLNDIV ILQLNGSATI NANVQVAQLP AQGRRLGNGV QCLAMGWGLL GRNRGIASVL QELNVTVVTS LCRRSNVCTL VRGRQAGVCF GDSGSPLVCN GLIHGIASFV RGGCASGLYP DAFAPVAQFV NWIDSIIQRS EDNPCPHPRD PDPASRTH
Target Information
The neutrophil form of elastase is 218 amino acids long, with two asparagine-linked carbohydrate chains (see glycosylation). It is present in azurophil granules in the neutrophil cytoplasm. There appear to be two forms of neutrophil elastase, termed IIa and IIb.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bone marrow serine protease; ELA2A; Elastase; elastase 2, neutrophil; elastase-2; elastase/medullasin precursor (EC 3.4.21.37); Elastase2; granulocyte-derived elastase; leukocyte elastase; medullasin; neutrophil elastase precursor; neutrophil elastase precursor (EC 3.4.21.37); PE-1; PMN elastase; polymorphonuclear elastase; polymorphonuclear leukocyte elastase; unnamed protein product
Gene Aliases: ELA2; F430011M15Rik; GE; HLE; HNE; NE; PMN-E; SCN1
UniProt ID: (Human) P08246, (Mouse) Q3UP87
Entrez Gene ID: (Human) 1991, (Mouse) 50701, (Rat) 299606
negative regulation of transcription from RNA polymerase II promoter
response to yeast
acute inflammatory response to antigenic stimulus
leukocyte migration involved in inflammatory response
biosynthetic process of antibacterial peptides active against Gram-negative bacteria
proteolysis
phagocytosis
response to UV
negative regulation of heterochromatin assembly
response to lipopolysaccharide
negative regulation of chemokine production
negative regulation of interleukin-8 production
positive regulation of interleukin-8 production
defense response to bacterium
positive regulation of smooth muscle cell proliferation
positive regulation of immune response
defense response to fungus
leukocyte migration
neutrophil-mediated killing of symbiont cell
neutrophil mediated killing of bacterium
neutrophil mediated killing of gram-negative bacterium
neutrophil mediated killing of fungus
neutrophil extracellular trap formation
positive regulation of leukocyte tethering or rolling
cellular calcium ion homeostasis
extracellular matrix disassembly
protein catabolic process
positive regulation of MAP kinase activity
negative regulation of inflammatory response
negative regulation of chemotaxis
pyroptosis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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