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Invitrogen
RCC2 Polyclonal Antibody
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FIGURE: 1 / 1
RCC2 Antibody (PA5-88987) in WB
Western blot analysis of RCC2 in extracts of various cell lines. Samples were incubated with RCC2 Polyclonal antibody (Product # PA5-88987) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-88987
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 323-522 of human RCC2 (NP_0011296761)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.74 mg/mL
Amount
74 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QILPVPNVVV RDVACGANHT LVLDSQKRVF SWGFGGYGRL GHAEQKDEMV PRLVKLFDFP GRGASQIYAG YTCSFAVSEV GGLFFWGATN TSRESTMYPK AVQDLCGWRI RSLACGKSSI IVAADESTIS WGPSPTFGEL GYGDHKPKSS TAAQEVKTLD GIFSEQVAMG YSHSLVIARD ESETEKEKIK KLPEYNPRTL; Positive Samples: U-87MG, Jurkat; Cellular Location: Chromosome, Cytoplasm, Nucleus, centromere, cytoskeleton, nucleolus, spindle
Target Information
Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; RCC1-like protein TD-60; telophase disk protein of 60 kDa
Gene Aliases: TD-60
UniProt ID: (Human) Q9P258
Entrez Gene ID: (Human) 55920
integrin-mediated signaling pathway
regulation of fibroblast migration
positive regulation of G2/M transition of mitotic cell cycle
regulation of cell migration
negative regulation of GTPase activity
establishment of protein localization
focal adhesion assembly
negative regulation of focal adhesion assembly
positive regulation of attachment of spindle microtubules to kinetochore
chromosome passenger complex localization to kinetochore
negative regulation of substrate adhesion-dependent cell spreading
regulation of ruffle assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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