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Invitrogen
ZAK Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-89875
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.76 mg/mL
Amount
176 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EEMDMDHIMT WATDVAKGMH YLHMEAPVKV IHRDLKSRNV VIAADGVLKI CDFGASRFHN HTTHMSLVGT FPWMAPEVIQ SLPVSETCDT YSYGVVLWEM LTREVPFKGL EGLQVAWLVV EKNERLTIPS SCPRSFAELL HQCWEADAKK RPSFKQIISI LESMSNDTSL PDKCNSFLHN KAEWRCEIEA TLERLKKLER DLSFKEQELK ERE; Positive Samples: Mouse heart, Mouse brain, Mouse skeletal muscle, Rat heart, Rat skeletal muscle; Cellular Location: Cytoplasm, Nucleus
Target Information
ZAK is a leucine zipper-containing mitogen-activated protein related to the MLKs in both sequence and function. Like the MLKs and other MAP3Ks, ZAK activates MAP2Ks. ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif. This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: human cervical cancer suppressor gene 4 protein; leucine zipper- and sterile alpha motif kinase ZAK; leucine zipper- and sterile alpha motif-containing kinase; mitogen-activated protein kinase kinase kinase MLT; mixed lineage kinase-related kinase; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; sterile alpha motif and leucine zipper containing kinase AZK; unnamed protein product
Gene Aliases: B230120H23Rik; HCCS-4; MLTK; MLTKalpha; MLTKbeta; MRK; RGD1561394; Zak
UniProt ID: (Mouse) Q9ESL4
Entrez Gene ID: (Mouse) 65964, (Rat) 311743
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
MAP kinase kinase kinase activity
ATP binding
protein kinase regulator activity
protein kinase activator activity
ribosome binding
small ribosomal subunit rRNA binding
protein serine kinase activity
stalled ribosome sensor activity
DNA damage checkpoint
MAPK cascade
translational initiation
protein phosphorylation
inflammatory response
cytoskeleton organization
JNK cascade
stress-activated protein kinase signaling cascade
intracellular signal transduction
p38MAPK cascade
embryonic digit morphogenesis
positive regulation of apoptotic process
positive regulation of programmed cell death
protein autophosphorylation
stress-activated MAPK cascade
protein maturation
limb development
pyroptosis
negative regulation of stress-activated protein kinase signaling cascade
cellular response to gamma radiation
cellular response to UV-B
GCN2-mediated signaling
negative regulation of translation in response to endoplasmic reticulum stress
positive regulation of mitotic DNA damage checkpoint
NLRP1 inflammasome complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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