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Invitrogen

TLR9 Polyclonal Antibody

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TLR9 Polyclonal Antibody

Product Details

PA5-89960

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.55 mg/mL

Amount

155 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2805867

Product Specific Information

Positive Samples: Mouse spleen, Rat spleen; Cellular Location: Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Single-pass type I membrane protein, phagosome

Immunogen sequence: FPGLRYVDLS DNRISGASEL TATMGEADGG EKVWLQPGDL APAPVDTPSS EDFRPNCSTL NFTLDLSRNN LVTVQPEMFA QLSHLQCLRL SHNCISQAVN GSQFLPLTGL QVLDLSHNKL DLYHEHSFTE

Target Information

The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: immune recognition; member of the toll-like receptor family; orphan receptor; TLR9; unspliced isoform

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Gene Aliases: CD289

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UniProt ID: (Human) Q9NR96, (Mouse) Q9EQU3

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Entrez Gene ID: (Human) 54106, (Mouse) 81897, (Rat) 338457

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Function(s)
interleukin-1 receptor binding siRNA binding pattern recognition receptor activity protein homodimerization activity unmethylated CpG binding protein binding
Process(es)
microglial cell activation positive regulation of cytokine production regulation of protein phosphorylation activation of innate immune response pattern recognition receptor signaling pathway toll-like receptor signaling pathway response to molecule of bacterial origin positive regulation of immunoglobulin production regulation of dendritic cell cytokine production MyD88-dependent toll-like receptor signaling pathway immune response signal transduction I-kappaB kinase/NF-kappaB signaling male gonad development response to virus positive regulation of autophagy positive regulation of gene expression maintenance of gastrointestinal epithelium positive regulation of B cell proliferation positive regulation of type I interferon production detection of molecule of bacterial origin positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production toll-like receptor 9 signaling pathway positive regulation of toll-like receptor 9 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade innate immune response regulation of B cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium regulation of B cell activation positive regulation of B cell activation defense response to virus negative regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to metal ion positive regulation of NLRP3 inflammasome complex assembly negative regulation of calcium-transporting ATPase activity cellular response to chloroquine positive regulation of intracellular signal transduction positive regulation of intestinal epithelial cell development defense response defense response to bacterium response to other organism endolysosomal toll-like receptor signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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