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Invitrogen

HEY2 Polyclonal Antibody

View all (13) HEY2 antibodies

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HEY2 Polyclonal Antibody

Product Details

PA5-90250

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HEY2 (NP_0363911)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.98 mg/mL

Amount

198 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2805982

Product Specific Information

Positive Samples: A-549, K562, MCF7, mouse brain, rat heart; Cellular Location: Nucleus

Immunogen sequence: TIDVGSENNY SGQSTS

Target Information

Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cardiovascular basic helix-loop-helix factor 1; cardiovascular helix-loop-helix factor 1; CHF1; class B basic helix-loop-helix protein 32; h hHRT2; hairy and enhancer of split related 2; hairy and enhancer of split-related protein 2; Hairy-E(spl)-related with YRPW motif 2; hairy-related transcription factor 2; hairy/enhancer-of-split related with YRPW motif 2; hCHF1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-2; hGRL; basic helix-loop-helix transcription factor; hHRT2; HRT-2; HRT2; mHRT2; protein gridlock homolog; transcription factor; unnamed protein product

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Gene Aliases: bHLHb32; CHF1; GRIDLOCK; GRL; HERP1; HESR2; HRT2

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UniProt ID: (Human) Q9UBP5, (Mouse) Q9QUS4

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Entrez Gene ID: (Human) 23493, (Mouse) 15214, (Rat) 155430

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding identical protein binding histone deacetylase binding sequence-specific DNA binding protein dimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter blood vessel development vasculogenesis muscular septum morphogenesis outflow tract morphogenesis atrioventricular valve development aortic valve morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis tricuspid valve morphogenesis tricuspid valve formation endocardial cushion to mesenchymal transition involved in heart valve formation cardiac ventricle morphogenesis cardiac left ventricle morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis cardiac muscle hypertrophy regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Notch signaling pathway pattern specification process heart development muscle organ development anterior/posterior axis specification anterior/posterior pattern specification positive regulation of heart rate regulation of gene expression negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process mesenchymal cell development striated muscle tissue development cardiac muscle hypertrophy in response to stress ascending aorta morphogenesis dorsal aorta morphogenesis umbilical cord morphogenesis cell fate commitment regulation of auditory receptor cell differentiation regulation of neuron differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter anatomical structure formation involved in morphogenesis tissue morphogenesis regulation of neurogenesis negative regulation of smooth muscle cell differentiation ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition heart trabecula formation cardiac septum morphogenesis ventricular septum morphogenesis atrial septum morphogenesis negative regulation of transcription initiation from RNA polymerase II promoter labyrinthine layer blood vessel development artery development arterial endothelial cell differentiation cardiac vascular smooth muscle cell development coronary vasculature morphogenesis pulmonary artery morphogenesis protein-DNA complex assembly negative regulation of biomineral tissue development circulatory system development cochlea development vascular smooth muscle cell development negative regulation of cardiac vascular smooth muscle cell differentiation regulation of vasculogenesis cardiac conduction system development epithelial to mesenchymal transition involved in endocardial cushion formation anatomical structure morphogenesis smooth muscle cell differentiation
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