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Invitrogen
Collagen II Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-90574
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic Peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Mouse liver; Cellular Location: extracellular matrix, extracellular space
Target Information
COL2A1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-1 type II collagen; arthroophthalmopathy, progressive (Stickler syndrome); cartilage collagen; CGA; chondrocalcin; COL2A1; Collagen 2; Collagen alpha-1(II) chain; collagen II, alpha-1 polypeptide; collagen, type II, alpha 1; disproportionate micromelia; MGC131516; procollagen, type II, alpha 1; unnamed protein product
Gene Aliases: ACG2; ANFH; ANFH1; AOM; COL11A3; Col2; Col2a; Col2a-1; COL2A1; Del1; Dmm; EDMMD; LCPD; Lpk; M100856; OSCDP; PLSDT; Rgsc856; SEDC; SEDSTN; SEMDSTWK; SMDALG; STL1; VPED
UniProt ID: (Mouse) P28481
Entrez Gene ID: (Human) 1280, (Mouse) 12824
extracellular matrix structural constituent
protein binding
extracellular matrix structural constituent conferring tensile strength
MHC class II protein binding
identical protein binding
protein homodimerization activity
proteoglycan binding
platelet-derived growth factor binding
metal ion binding
extracellular matrix structural protein
skeletal system development
ossification
chondrocyte differentiation
central nervous system development
visual perception
sensory perception of sound
collagen fibril organization
notochord development
animal organ development
skeletal system morphogenesis
system development
cartilage development
limb bud formation
embryonic skeletal joint morphogenesis
otic vesicle development
cartilage condensation
tissue homeostasis
endochondral ossification
heart morphogenesis
proteoglycan metabolic process
regulation of gene expression
limb morphogenesis
inner ear morphogenesis
inner ear development
palate development
bone development
cartilage development involved in endochondral bone morphogenesis
cellular response to BMP stimulus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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