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Invitrogen

ATP1A3 Polyclonal Antibody

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ATP1A3 Polyclonal Antibody

Product Details

PA5-90893

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.76 mg/mL

Amount

76 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806277

Product Specific Information

Immunogen sequence: MGDKKDDKDS PKKNKGKERR DLDDLKKEVA MTEHKMSVEE VCRKYNTDCV QGLTHSKAQE; Positive Samples: Mouse liver, Rat liver; Cellular Location: Cell membrane, Multi-pass membrane protein

Target Information

The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: (Na+ and K+) ATPase, alpha(III) catalytic subunit; ATPase, Na+/K+ transporting, alpha 3 polypeptide; ATPase, Na+K+ transporting, alpha 3 subunit; EC 3.6.3.9; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+/K+ -ATPase alpha 3 subunit; NA,K-ATPase alpha subunit 3; Sodium Potassium ATPase; Sodium pump 3; sodium pump subunit alpha-3; unnamed protein product

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Gene Aliases: Atpa-2; Atpa1a3

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UniProt ID: (Mouse) Q6PIC6, (Rat) P06687

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Entrez Gene ID: (Mouse) 232975, (Rat) 24213

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Function(s)
nucleotide binding beta-amyloid binding sodium:potassium-exchanging ATPase activity ATP binding potassium-transporting ATPase activity ATPase activity D1 dopamine receptor binding heparan sulfate proteoglycan binding chaperone binding protein binding
Process(es)
potassium ion transport sodium ion transport cellular sodium ion homeostasis response to stress gamma-aminobutyric acid signaling pathway learning memory circadian rhythm locomotory behavior blood circulation determination of adult lifespan adult locomotory behavior visual learning response to temperature stimulus response to xenobiotic stimulus response to hormone response to lithium ion establishment or maintenance of transmembrane electrochemical gradient response to activity transmission of nerve impulse calcium-mediated signaling L-ascorbic acid metabolic process thalamus development cerebral cortex development neurogenesis cellular potassium ion homeostasis sleep brain-derived neurotrophic factor receptor signaling pathway social behavior ionotropic glutamate receptor signaling pathway multicellular organism growth response to potassium ion response to immobilization stress sodium ion export from cell locomotion fear response protein kinase B signaling pore complex assembly carboxylic acid transport habituation regulation of short-term neuronal synaptic plasticity neuromuscular process controlling balance cognition neuromuscular process response to electrical stimulus membrane depolarization cardiac muscle contraction motor behavior ERK1 and ERK2 cascade response to monoamine regulation of cardiac muscle cell membrane potential response to environmental enrichment walking behavior inhibitory chemical synaptic transmission hydrogen ion transmembrane transport response to methamphetamine hydrochloride cellular response to beta-amyloid neuron projection maintenance potassium ion import across plasma membrane cellular response to retinoic acid cellular response to thyroid hormone stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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