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Invitrogen
MRE11 Polyclonal Antibody
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FIGURE: 1 / 4
MRE11 Antibody (PA5-95501) in IHC (P)
Immunohistochemistry analysis of MRE11 in paraffin-embedded human mammary cancer tissue. Antigen retrieval was performed on the tissue using citrate buffer (pH 6, 20 min) and blocked with 10% goat serum. Samples were incubated with MRE11 polyclonal antibody (Product # PA5-95501) at a 1 µg/mL dilution, followed by biotinylated goat anti-rabbit IgG (30 min, 37°C), and developed with Strepavidin-Biotin-Complex... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-95501
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human MRE11 recombinant protein (Position: S2-D239).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human MCF-7 whole cell, human COLO-320 whole cell, human U-87MG whole cell, rat brain tissue, rat liver tissue, mouse brain tissue, mouse liver tissue. IHC: human colon cancer tissue, human lung cancer tissue, human mammary cancer tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
MRE11 (double-strand break repair protein MRE11) is a component of the MRN complex. This complex plays a central role in double-strand break repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-stranded endonuclease activity and double-strand-specific 3'-5' exonuclease activity which are provided by MRE11. RAD50 is required to bind DNA ends and hold them in close proximity. Mutations in the gene could result in ataxia-telangiectasia-like disorder 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AT-like disease; DNA recombination and repair protein; double-strand break repair protein MRE11A; endo/exonuclease; endo/exonuclease Mre11; hMRE11B; Mre11 homolog; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; mmMRE11A; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae) isoform MRE11A_1; MRE11 meiotic recombination 11 homolog A (S. cerevisiae) isoform MRE11A_2; MRE11 meiotic recombination 11-like protein A; unnamed protein product
Gene Aliases: ATLD; HNGS1; Mre11; MRE11A; MRE11B
UniProt ID: (Human) P49959, (Rat) Q9JIM0, (Mouse) Q61216
Entrez Gene ID: (Human) 4361, (Rat) 64046, (Mouse) 17535
single-stranded DNA endodeoxyribonuclease activity
DNA binding
DNA helicase activity
double-stranded DNA binding
nuclease activity
endonuclease activity
endodeoxyribonuclease activity
protein binding
3'-5'-exodeoxyribonuclease activity
3'-5' exonuclease activity
hydrolase activity
manganese ion binding
identical protein binding
cadherin binding
telomere maintenance
double-strand break repair via homologous recombination
DNA double-strand break processing
double-strand break repair
double-strand break repair via nonhomologous end joining
cellular response to DNA damage stimulus
sister chromatid cohesion
mitotic G2 DNA damage checkpoint
heart development
intra-S DNA damage checkpoint
telomeric 3' overhang formation
positive regulation of telomere maintenance
meiotic DNA double-strand break formation
negative regulation of apoptotic process
negative regulation of viral entry into host cell
chromosome organization
R-loop processing
mitochondrial double-strand break repair via homologous recombination
DNA strand resection involved in replication fork processing
positive regulation of double-strand break repair
negative regulation of double-strand break repair via nonhomologous end joining
regulation of mitotic recombination
DNA repair
DNA recombination
telomere maintenance via telomerase
reciprocal meiotic recombination
reciprocal DNA recombination
mitotic G2/M transition checkpoint
synapsis
cell proliferation
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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