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Invitrogen
CHRNB4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-95643
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein from the cytoplasmic loop of the beta 4 subunit of rat nAChR
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.15 mg/mL
Amount
15 µg
Purification
Antigen Affinity Chromatography
Storage buffer
10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 0.15M NaCl
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antigen Affinity Purified from Pooled Serum
Target Information
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acetylcholine receptor; Acetylcholine receptor beta 4; cholinergic receptor; cholinergic receptor, nicotinic beta 4; cholinergic receptor, nicotinic, beta 4 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 4; N-alpha 2; nAChRB4; neuronal acetylcholine receptor non-alpha-2 chain; neurotransmitter receptor subunit; nicotinic acetylcholine receptor beta4 subunit; nicotinic acetylcholine receptor-related protein; unnamed protein product
Gene Aliases: Acrb-4; Acrb4
UniProt ID: (Mouse) Q8R493, (Rat) P12392
Entrez Gene ID: (Mouse) 108015, (Rat) 25103
transmembrane signaling receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
acetylcholine receptor activity
acetylcholine-gated cation channel activity
acetylcholine binding
macromolecular complex binding
heterocyclic compound binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
protein binding
action potential
ion transport
calcium ion transport
smooth muscle contraction
regulation of smooth muscle contraction
signal transduction
synaptic transmission, cholinergic
locomotory behavior
regulation of appetite
ion transmembrane transport
response to nicotine
behavioral response to nicotine
regulation of membrane potential
membrane depolarization
positive regulation of transmission of nerve impulse
regulation of postsynaptic membrane potential
excitatory postsynaptic potential
synaptic transmission involved in micturition
acetylcholine receptor signaling pathway
chemical synaptic transmission, postsynaptic
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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