Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

HDAC6 Polyclonal Antibody

View all (44) HDAC6 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
HDAC6 Polyclonal Antibody

Product Details

PA5-95908

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human HDAC6 (NP_0060352)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.59 mg/mL

Amount

59 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807710

Product Specific Information

Immunogen sequence: MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV KKKGKMKKLG QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHSLEYI DLMETTQYMN EGELRVLADT YDSVYLHPNS YSCACLASGS VLRLVDAVLG; Positive Samples: K-562, HeLa; Cellular Location: Cell projection, Cytoplasm, Nucleus, Perikaryon, axon, dendrite

Target Information

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: alpha-tubulin deacetylase HDAC6; E3 ubiquitin-protein ligase HDAC6; FLJ16239; HDA6; HDAC6; histone deacetylase 5; histone deacetylase 6; histone deacetylase mHDA2; protein phosphatase 1, regulatory subunit 90; scurfy candidate 6; tubulin-lysine deacetylase HDAC6; unnamed protein product

View more View less

Gene Aliases: CPBHM; HD6; Hdac5; JM21; KDAC6; mHDA2; PPP1R90; Sfc6

View more View less

UniProt ID: (Human) Q9UBN7, (Mouse) Q9Z2V5

View more View less

Entrez Gene ID: (Human) 10013, (Mouse) 15185

View more View less

Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription corepressor binding histone deacetylase activity protein binding beta-catenin binding microtubule binding zinc ion binding deacetylase activity enzyme binding polyubiquitin binding ubiquitin protein ligase binding protein deacetylase activity peroxidase inhibitor activity ATPase inhibitor activity histone deacetylase binding tubulin deacetylase activity alpha-tubulin binding ubiquitin binding acetylspermidine deacetylase activity tau protein binding beta-tubulin binding misfolded protein binding Hsp90 protein binding ubiquitin protein ligase activity dynein complex binding
Process(es)
protein deacetylation misfolded or incompletely synthesized protein catabolic process intracellular protein transport response to stress epidermal growth factor receptor signaling pathway regulation of autophagy positive regulation of epithelial cell migration negative regulation of hydrogen peroxide metabolic process macroautophagy regulation of macroautophagy protein ubiquitination axonal transport of mitochondrion negative regulation of protein complex assembly regulation of protein stability protein destabilization lysosome localization positive regulation of protein oligomerization regulation of microtubule-based process positive regulation of intracellular estrogen receptor signaling pathway cellular response to heat cellular response to topologically incorrect protein negative regulation of protein complex disassembly negative regulation of gene expression, epigenetic negative regulation of proteolysis negative regulation of transcription, DNA-templated negative regulation of cellular component organization positive regulation of cellular component organization mitochondrion localization response to misfolded protein cilium morphogenesis regulation of microtubule-based movement regulation of androgen receptor signaling pathway cilium disassembly parkin-mediated mitophagy in response to mitochondrial depolarization cellular response to hydrogen peroxide aggresome assembly polyubiquitinated misfolded protein transport tubulin deacetylation macromolecule deacylation regulation of mitophagy positive regulation of type 2 mitophagy negative regulation of aggrephagy protein polyubiquitination regulation of protein phosphorylation chromatin organization ubiquitin-dependent protein catabolic process actin filament organization negative regulation of microtubule depolymerization regulation of mitochondrion organization negative regulation of neuron projection development protein-containing complex disassembly protein deacylation aggrephagy erythrocyte enucleation ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway regulation of fat cell differentiation collateral sprouting negative regulation of axon extension involved in axon guidance positive regulation of dendrite morphogenesis response to corticosterone positive regulation of synaptic transmission, glutamatergic dendritic spine morphogenesis regulation of establishment of protein localization regulation of microtubule cytoskeleton organization Hsp90 deacetylation protein targeting to vacuole involved in autophagy cellular response to misfolded protein positive regulation of tubulin deacetylation membraneless organelle assembly positive regulation of cellular response to oxidative stress negative regulation of protein acetylation positive regulation of cholangiocyte proliferation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support