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Invitrogen
Neuromedin U Polyclonal Antibody
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FIGURE: 1 / 1
Neuromedin U Antibody (PA5-96566) in WB
Western blot analysis of Neuromedin U in extracts of various cell lines. Samples were incubated with Neuromedin U Polyclonal antibody (Product # PA5-96566) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-96566
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.86 mg/mL
Amount
286 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive samples: Mouse large intestine, Mouse stomach, Rat large intestine, Rat stomach; Cellular location: Secreted
Immunogen sequence: ACRGAPILPQ GLQPEQQLQL WNEIDDTCSS FLSIDSQPQA SNALEELCFM IMGMLPKPQE QDEKDNTKRF LFHYSKTQKL GKSNVVSSVV HPLLQLVPHL HERRMKRFRV DEEFQSPFAS QSRGYFLFRP RNGRRSAGFI
Target Information
This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: neuroendocrine peptide; neuromedin U precursor-related peptide/neuromedin U preproprotein; NmU 25; prepro-NMU; unnamed protein product
UniProt ID: (Human) P48645, (Rat) P12760, (Mouse) Q9QXK8
Entrez Gene ID: (Human) 10874, (Rat) 63887, (Mouse) 56183
temperature homeostasis
gastric acid secretion
positive regulation of T cell cytokine production
positive regulation of systemic arterial blood pressure
regulation of smooth muscle contraction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
photoperiodism
positive regulation of heart rate
positive regulation of heat generation
eating behavior
regulation of circadian sleep/wake cycle, sleep
positive regulation of smooth muscle contraction
positive regulation of hormone secretion
positive regulation of synaptic transmission
regulation of feeding behavior
negative regulation of gastric acid secretion
negative regulation of insulin secretion involved in cellular response to glucose stimulus
energy homeostasis
negative regulation of gastric emptying
positive regulation of stomach fundus smooth muscle contraction
positive regulation of prolactin secretion
negative regulation of eating behavior
positive regulation of sensory perception of pain
negative regulation of feeding behavior
regulation of grooming behavior
positive regulation of blood pressure
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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