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Invitrogen

AMPK alpha-2 Polyclonal Antibody

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AMPK alpha-2 Polyclonal Antibody

Product Details

PA5-96645

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.56 mg/mL

Amount

56 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808447

Product Specific Information

Positive Samples: SW620, NCI-H460, Mouse brain, Mouse heart, Rat skeletal muscle; Cellular Location: Cytoplasm, Nucleus

Immunogen sequence: QDLPSYLFPE DPSYDANVID DEAVKEVCEK FECTESEVMN SLYSGDPQDQ LAVAYHLIID NRRIMNQASE FYLA

Target Information

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5'-AMP-activated protein kinase, catalytic alpha-2 chain; ACACA kinase; acetyl-CoA carboxylase kinase; AMP-activated protein kinase; AMPK alpha 2; AMPK alpha-2 chain; AMPK alpha-2 variant 2; AMPK alpha-2 variant 3; AMPK subunit alpha-2; AMPK-alpha-2 chain; EC 2.7.11.1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase; protein kinase, AMP-activated, alpha 2 catalytic subunit; unnamed protein product

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Gene Aliases: 2310008I11Rik; A830082D05; AMPK; AMPK2; AMPKa2; AMPKalpha2; PRKAA

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UniProt ID: (Human) P54646, (Rat) Q09137, (Mouse) Q8BRK8

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Entrez Gene ID: (Human) 5563, (Rat) 78975, (Mouse) 108079

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Function(s)
chromatin binding protein kinase activity protein serine/threonine kinase activity AMP-activated protein kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity protein serine kinase activity histone H2BS36 kinase activity protein binding, bridging macromolecular complex binding
Process(es)
chromatin remodeling protein phosphorylation lipid biosynthetic process regulation of gene expression positive regulation of autophagy negative regulation of gene expression response to activity response to muscle activity regulation of macroautophagy peptidyl-serine phosphorylation regulation of lipid metabolic process response to caffeine cellular response to nutrient levels negative regulation of TOR signaling adiponectin-activated signaling pathway cellular response to oxidative stress cellular response to glucose starvation glucose homeostasis regulation of circadian rhythm negative regulation of apoptotic process positive regulation of glycolytic process fatty acid homeostasis regulation of stress granule assembly regulation of microtubule cytoskeleton organization cellular response to calcium ion cellular response to glucose stimulus cellular response to prostaglandin E stimulus cellular response to xenobiotic stimulus energy homeostasis positive regulation of cellular protein localization negative regulation of hepatocyte apoptotic process negative regulation of TORC1 signaling lipid droplet disassembly protein localization to lipid particle cytoplasmic translation phosphatidylethanolamine biosynthetic process phosphatidylcholine biosynthetic process cellular response to starvation positive regulation of catabolic process cellular response to amino acid starvation TORC1 signaling negative regulation of translational initiation positive regulation of translational initiation protein localization to lysosome protein K6-linked ubiquitination positive regulation of release of cytochrome c from mitochondria hepatocyte apoptotic process positive regulation of TORC1 signaling signal transduction positive regulation of macroautophagy
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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