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          • Primary Antibodies ›
          • EphA2/EphA3/EphA4 Antibodies

          Invitrogen

          EphA2/EphA3/EphA4 Polyclonal Antibody

          View all (3) EphA2/EphA3/EphA4 antibodies

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          Cite EphA2/EphA3/EphA4 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          EphA2/EphA3/EphA4 Antibody in Western Blot (WB)
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          EphA2/EphA3/EphA4 Antibody in Western Blot (WB)
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          EphA2/EphA3/EphA4 Antibody (PA5-99153) in WB

          Western blot analysis of EphA2/EphA3/EphA4 in HepG2 cell lysates (left lane: treated with the antigen-specific peptide). Samples were incubated with EphA2/EphA3/EphA4 polyclonal antibody (Product # PA5-99153). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          EphA2/EphA3/EphA4 Antibody in Western Blot (WB)
          EphA2/EphA3/EphA4 Polyclonal Antibody

          Product Details

          PA5-99153

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:500
          -
          Product Specifications

          Species Reactivity

          Human, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human EPHA2(Accession P29317), corresponding to amino acid residues R568-V618.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2818086

          Product Specific Information

          Antibody detects endogenous levels of total EPHA2/3/4.

          Target Information

          The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. While the biological activities of these receptors have yet to be determined, there is increasing evidence that they are involved in central nervous system function and in development. The Eph subfamily receptors of human origin (and their murine/avian homologs) include EphA1(Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12),EphA7 (Hek11/MDK1), EphA8 (Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3(Cek10, Hek2), EphB4 (Htk), EphB5 (Hek9) and EphB6 (Mep). Ligands for Eph receptors include ephrin-A4 (LERK-4) which binds EphA3 and EphB1. In addition, Ephrin-A2 (Elf-1) has been described as the ligand for EphA4, ephrin-A3 (Ehk1-L) as the ligand for EphA5 and ephrin-B2 (Htk-L) as the ligand for EphB4 (Htk).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: EK4; EK8; EPH-like kinase 4; EPH-like kinase 8; Eph-like tyrosine kinase 1; Ephrin A2; Ephrin A3; Ephrin A4; ephrin receptor EphA2; Ephrin type-A receptor 2; Ephrin type-A receptor 3; Ephrin type-A receptor 4; EphrinA2; EphrinA3; EphrinA4; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; HEK; Human embryo kinase; human embryo kinase 1; receptor protein-tyrosine kinase HEK8; rEK4; soluble receptor; testicular tissue protein Li 64; TYRO1 protein tyrosine kinase; TYRO4 protein tyrosine kinase; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor ETK1; tyrosine-protein kinase receptor REK4; Tyrosine-protein kinase receptor SEK; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase TYRO4; unnamed protein product

          View more View less

          Gene Aliases: ARCC2; CTPA; CTPP1; CTRCT6; ECK; EK4; EK8; EPHA2; EPHA3; EPHA4; ETK; ETK1; HEK; HEK4; HEK8; Rek4; RGD1560587; SEK; TYRO1; TYRO4

          View more View less

          UniProt ID: (Human) P29317, (Human) P29320, (Human) P54764, (Rat) O08680

          View more View less

          Entrez Gene ID: (Human) 1969, (Human) 2042, (Human) 2043, (Rat) 366492, (Rat) 29210, (Rat) 316539

          View more View less

          Function(s)
          nucleotide binding virus receptor activity protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity protein binding ATP binding kinase activity transferase activity growth factor binding cadherin binding molecular function activator activity GPI-linked ephrin receptor activity transmembrane-ephrin receptor activity beta-amyloid binding PH domain binding identical protein binding ephrin receptor binding DH domain binding protein tyrosine kinase binding molecular_function transmembrane signal receptor
          Process(es)
          skeletal system development angiogenesis blood vessel development vasculogenesis osteoblast differentiation negative regulation of cytokine production blood vessel endothelial cell proliferation involved in sprouting angiogenesis apoptotic process response to stress inflammatory response cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage regulation of lamellipodium assembly notochord formation cell migration negative regulation of angiogenesis neural tube development central nervous system neuron differentiation cell differentiation regulation of cell adhesion keratinocyte differentiation osteoclast differentiation regulation of cell migration positive regulation of cell migration epithelial cell differentiation negative regulation of chemokine production mammary gland epithelial cell proliferation regulation of cell adhesion mediated by integrin post-anal tail morphogenesis regulation of blood vessel endothelial cell migration regulation of angiogenesis cAMP metabolic process viral entry into host cell bone remodeling ephrin receptor signaling pathway axial mesoderm formation animal organ development blood vessel morphogenesis notochord morphogenesis cell motility defense response to Gram-positive bacterium notochord cell development cell chemotaxis branching involved in mammary gland duct morphogenesis lens fiber cell morphogenesis regulation of ERK1 and ERK2 cascade response to growth factor protein localization to plasma membrane activation of GTPase activity negative regulation of lymphangiogenesis positive regulation of protein localization to plasma membrane positive regulation of bicellular tight junction assembly pericyte cell differentiation axon guidance regulation of epithelial to mesenchymal transition positive regulation of neuron projection development peptidyl-tyrosine phosphorylation regulation of actin cytoskeleton organization regulation of GTPase activity negative regulation of endocytosis regulation of focal adhesion assembly regulation of microtubule cytoskeleton organization cellular response to retinoic acid fasciculation of sensory neuron axon fasciculation of motor neuron axon deadenylation-dependent decapping of nuclear-transcribed mRNA negative regulation of cell adhesion nervous system development adult walking behavior motor neuron axon guidance positive regulation of cell proliferation glial cell migration negative regulation of epithelial to mesenchymal transition negative regulation of neuron projection development negative regulation of translation corticospinal tract morphogenesis negative regulation of cell migration adherens junction organization negative regulation of neuron apoptotic process positive regulation of cell adhesion negative regulation of translational initiation positive regulation of JNK cascade negative regulation of axon regeneration regulation of astrocyte differentiation regulation of axonogenesis positive regulation of dendrite morphogenesis protein stabilization innervation regulation of dendritic spine morphogenesis negative regulation of ERK1 and ERK2 cascade nephric duct morphogenesis cochlea development neuron projection guidance synapse pruning neuron projection fasciculation membraneless organelle assembly negative regulation of cellular response to hypoxia negative regulation of long-term synaptic potentiation positive regulation of beta-amyloid formation positive regulation of intracellular signal transduction positive regulation of amyloid precursor protein catabolic process negative regulation of proteolysis involved in cellular protein catabolic process cellular response to beta-amyloid regulation of modification of synaptic structure regulation of synapse pruning neuron differentiation protein kinase B signaling negative regulation of protein kinase B signaling positive regulation of establishment of protein localization to plasma membrane fever generation endocardial cushion development response to lipopolysaccharide response to cytokine positive regulation of JUN kinase activity protein autophosphorylation positive regulation of Rho guanyl-nucleotide exchange factor activity
          It has to be done as per old AB suggested Products section.

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