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Invitrogen
MAGI2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-99245
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MAGI2(Accession Q86UL8), corresponding to amino acid residues E235-E285.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MAGI2.
Target Information
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team, Genome Res. 14:2121-2127(2004). Devroe E., J. Biol. Chem. 279:24444-24451(2004).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin receptor interacting protein 1; atrophin-1-interacting protein 1; atrophin-1-interacting protein A; MAGUK-like protein with 5 PDZ domains, 2 WW domains and a guanylate kinase-like domain; membrane-associated guanylate kinase inverted 2; synaptic-scaffolding molecule; unnamed protein product
Gene Aliases: Acvri1; Acvrinp1; ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2; mKIAA0705; NPHS15; S-SCAM; SSCAM
UniProt ID: (Human) Q86UL8, (Mouse) Q9WVQ1, (Rat) O88382
Entrez Gene ID: (Human) 9863, (Mouse) 50791, (Rat) 113970
protein binding
phosphatase binding
receptor signaling complex scaffold activity
beta-1 adrenergic receptor binding
SMAD binding
type II activin receptor binding
kinesin binding
macromolecular complex binding
activin receptor binding
structural constituent of postsynaptic specialization
structural constituent of postsynaptic density
positive regulation of receptor internalization
signal transduction
negative regulation of cell proliferation
positive regulation of neuron projection development
negative regulation of cell migration
negative regulation of activin receptor signaling pathway
nerve growth factor signaling pathway
receptor clustering
negative regulation of protein kinase B signaling
Wnt signaling pathway, planar cell polarity pathway
SMAD protein signal transduction
glomerular visceral epithelial cell development
clathrin-mediated endocytosis
cellular response to nerve growth factor stimulus
neuroligin clustering involved in postsynaptic membrane assembly
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
maintenance of postsynaptic specialization structure
postsynapse organization
regulation of synaptic membrane adhesion
maintenance of postsynaptic density structure
positive regulation of synaptic vesicle clustering
glomerular filtration
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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