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Invitrogen

Phospho-Lyn (Tyr508) Polyclonal Antibody

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View all (45) Lyn antibodies

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Phospho-Lyn (Tyr508) Polyclonal Antibody

Product Details

PA5-99355

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human LYN(Accession P07948), corresponding to amino acid residues around phosphorylated Tyr508.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818288

Product Specific Information

Antibody detects endogenous levels of Lyn only when phosphorylated at Tyrosine 507.

Target Information

Lyn proto oncogene (Lcl/Yes related novel protein tyrosine kinase) is encoded by the Lyn gene located on chromosome 8 in humans and belongs to the Src family kinase. It is a non-receptor tyrosine kinase that acts as a mediator in transducing cellular signaling. The most well studied expression of Lyn is in hematopoietic cell types, both lymphoid and myeloid cells with exclusion in T lymphocytes. It has also been observed that Lyn plays diverse roles such as in regulation of B cell receptor signaling, mast cell signaling and Epithelial - Mesenchymal Transition (EMT).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: FLJ26625; lck/Yes-related novel protein tyrosine kinase; lyn; lyn protein non-receptor kinase; lyn tyrosine kinase; protein-tyrosine kinase (EC 2.7.1.112); Src-family protein tyrosine kinase; unnamed protein product; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

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Gene Aliases: Hck-2; JTK8; p53Lyn; p56Lyn; SAIDV

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UniProt ID: (Human) P07948, (Mouse) P25911, (Rat) Q07014

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Entrez Gene ID: (Human) 4067, (Mouse) 17096, (Rat) 81515

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Function(s)
protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding platelet-derived growth factor receptor binding integrin binding protein binding ATP binding kinase activity enzyme binding receptor activator activity ubiquitin protein ligase binding immunoglobulin receptor binding gamma-tubulin binding glycosphingolipid binding ion channel binding macromolecular complex binding ephrin receptor binding phosphoprotein binding scaffold protein binding phosphorylation-dependent protein binding erythropoietin receptor binding SH3 domain binding phosphatidylinositol 3-kinase activator activity
Process(es)
DNA damage checkpoint cell morphogenesis B cell homeostasis regulation of cytokine production negative regulation of protein phosphorylation hematopoietic progenitor cell differentiation Fc receptor mediated stimulatory signaling pathway tolerance induction to self antigen histamine secretion by mast cell platelet degranulation negative regulation of myeloid leukocyte differentiation immune response-regulating cell surface receptor signaling pathway Fc receptor mediated inhibitory signaling pathway regulation of B cell apoptotic process protein phosphorylation autophagy defense response inflammatory response cellular response to DNA damage stimulus transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation response to hormone positive regulation of neuron projection development fatty acid transport vesicle-mediated transport peptidyl-tyrosine phosphorylation hemopoiesis erythrocyte differentiation eosinophil differentiation positive regulation of cell migration negative regulation of B cell proliferation neuron projection development lipopolysaccharide-mediated signaling pathway regulation of mast cell activation regulation of cell adhesion mediated by integrin negative regulation of toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway negative regulation of toll-like receptor 4 signaling pathway positive regulation of toll-like receptor 4 signaling pathway positive regulation of toll-like receptor 9 signaling pathway intracellular signal transduction interleukin-5-mediated signaling pathway C-X-C chemokine receptor CXCR4 signaling pathway B cell proliferation positive regulation of phosphorylation hemoglobin biosynthetic process regulation of mast cell degranulation negative regulation of MAP kinase activity positive regulation of MAPK cascade regulation of erythrocyte differentiation protein autophosphorylation ephrin receptor signaling pathway regulation of inflammatory response B cell receptor signaling pathway regulation of B cell receptor signaling pathway negative regulation of B cell receptor signaling pathway regulation of release of sequestered calcium ion into cytosol positive regulation of glial cell proliferation positive regulation of Fc receptor mediated stimulatory signaling pathway regulation of ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade positive regulation of oligodendrocyte progenitor proliferation negative regulation of mast cell proliferation positive regulation of mast cell proliferation cellular response to retinoic acid regulation of monocyte chemotaxis regulation of platelet aggregation dendritic cell differentiation neuroinflammatory response negative regulation of intracellular signal transduction positive regulation of amyloid precursor protein catabolic process positive regulation of protein localization to plasma membrane positive regulation of dendritic cell apoptotic process response to sterol depletion response to xenobiotic stimulus response to toxic substance response to carbohydrate oligodendrocyte development response to insulin cellular response to heat response to amino acid response to peptide hormone response to axon injury regulation of protein phosphorylation stimulatory C-type lectin receptor signaling pathway innate immune response-activating signal transduction negative regulation of inflammatory response to antigenic stimulus signal transduction T cell costimulation Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis negative regulation of immune response leukocyte migration JAK-STAT cascade involved in growth hormone signaling pathway cellular response to lipid
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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