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Invitrogen
Kir6.2 (KCNJ11) Polyclonal Antibody
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FIGURE: 1 / 8
Kir6.2 (KCNJ11) Antibody (PA5-99440) in ICC/IF
Immunofluorescent analysis of Kir6.2 (KCNJ11) in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Kir6.2 (KCNJ11) polyclonal antibody (Product # PA5-99440) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alex... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-99440
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Guinea pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KCNJ11(Accession Q14654), corresponding to amino acid residues L200-F250.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Kir6.2.
Target Information
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AI842722; AW491124; beta-cell inward rectifier subunit; BIR; inward rectifier K(+) channel Kir6.2; inwardly rectifing potassium channel subfamily J member 11; inwardly rectifying potassium channel KIR6.2; inwardly-rectifying potassium channel subfamily J member 11; IRK11; KATP; KATP channel; MGC133230; potassium channel inwardly rectifing subfamily J member 11; potassium channel, inwardly rectifying subfamily J member 11; potassium voltage-gated channel subfamily J member 11; unnamed protein product
Gene Aliases: BIR; HHF2; IKATP; KIR6.2; mBIR; MODY13; PHHI; PNDM2; TNDM3
UniProt ID: (Human) Q14654, (Mouse) Q61743, (Rat) P70673
Entrez Gene ID: (Human) 3767, (Mouse) 16514, (Rat) 83535
inward rectifier potassium channel activity
voltage-gated potassium channel activity
protein binding
ATP binding
ATP-activated inward rectifier potassium channel activity
cation-transporting ATPase activity
ankyrin binding
potassium ion binding
ion channel binding
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
heat shock protein binding
glucose metabolic process
potassium ion transport
response to xenobiotic stimulus
response to ATP
regulation of membrane potential
negative regulation of insulin secretion
regulation of insulin secretion
neurological system process
transmembrane transport
potassium ion transmembrane transport
inorganic cation import across plasma membrane
regulation of presynaptic membrane potential
potassium ion import across plasma membrane
action potential
response to hypoxia
response to ischemia
ventricular cardiac muscle tissue development
apoptotic process
response to stress
determination of adult lifespan
cellular response to nutrient levels
response to estradiol
response to testosterone
CAMKK-AMPK signaling cascade
cellular response to nicotine
cellular response to glucose stimulus
cellular response to tumor necrosis factor
positive regulation of protein localization to plasma membrane
response to resveratrol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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