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Invitrogen
TMEM67 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-99981
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TMEM67(Accession Q5HYA8), corresponding to amino acid residues H626-E676.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MKS3.
Target Information
The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: meckel syndrome type 3 protein; meckel syndrome type 3 protein homolog; unnamed protein product
Gene Aliases: 5330408M12Rik; B230117O07; b2b1163.1Clo; b2b1291.1Clo; JBTS6; MECKELIN; MKS3; NPHP11; TNEM67
UniProt ID: (Human) Q5HYA8, (Mouse) Q8BR76
Entrez Gene ID: (Human) 91147, (Mouse) 329795
kidney development
determination of left/right symmetry
heart development
negative regulation of centrosome duplication
non-canonical Wnt signaling pathway
photoreceptor cell outer segment organization
ERAD pathway
branching morphogenesis of an epithelial tube
cilium morphogenesis
head development
epithelial tube branching involved in lung morphogenesis
positive regulation of nonmotile primary cilium assembly
positive regulation of ERAD pathway
protein localization to ciliary transition zone
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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