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Invitrogen
Human FKBP5 (aa 394-407) Synthetic Peptide
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Product Details
PEP-078
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
50 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-078 is a 14 amino acid synthetic peptide whose sequence corresponds to residues 394-407 of human FKBP51 with a carboxy terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): C (394) -Q-K-K-A-K-E-H-N-E-R-D-R-R (407)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human FKBP51, catalog # PA1-020. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Target Information
FKBP5 is a member of the immunophilin protein family. This family plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP5 is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. The gene that encodes FKBP5 has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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