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Invitrogen
Human NDP Synthetic Peptide
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Product Details
PEP-0836
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
50 µg
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 18 amino acids near the amino terminus of human Norrin.
PEP-0836 can be used as a blocking peptide with polyclonal antibody PA5-20722.
Target Information
NDP (Norrie disease protein), also known as norrin, is a secreted signaling protein encoded by the NDP gene that activates the canonical Wnt/β-catenin pathway by binding the Frizzled-4 (FZD4)/LRP5 receptor complex. It plays an essential role in retinal vascular development, maintenance of the blood-retina barrier, and inner ear vascularization. Loss-of-function variants in NDP cause Norrie disease and can also contribute to familial exudative vitreoretinopathy (FEVR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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