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Invitrogen
Human Caveolin 1 (aa 1-17) Synthetic Peptide
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Product Details
PEP-146
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
50 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-146 is a 18 amino acid synthetic peptide whose sequence is from human caveolin-1. The sequence of this peptide is (amino to carboxy terminus): M (1)-S-G-G-K-Y-V-D-S-E-G-H-L-Y-T-V-P-C (18)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the human caveolin-1, catalog # PA1-064 and PA1.1-064. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
Reconstitute with 0.1 mL of distilled water.
Target Information
Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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