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MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes.
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Accession Number
NP_003945.2
Molecular Weight
96.9 kDa
Quantity
100μg
Gene Alias
MAP3K14 (NIK)
KinaseFamily
STE Unique Kinase Family
Recombinant
Yes
Protein Tag
GST Tag
Kinase Group
Ser⁄Thr Kinases: STE Group
Shipping Condition
Dry Ice
Expression System
Baculovirus
Protein Family
Kinases & Inhibitors
Protein Form
Recombinant, Catalytic
Form
Liquid
Validated Application
Kinase Assay
Species
Human
Research Category
Signal Transduction
Contents & Storage
Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.02% Trition X-100, 0.5 mM EDTA, 2 mM DTT, 50% Glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.