For order quantities > 1, multiple lots may be used to fulfill the order. If you require a single lot, please email discoverysciences@lifetech.com.

During checkout, this product will be reported as "Out of Stock" with an estimated availability date. Often, the actual availability date will be earlier. Send inquiries regarding actual availability date to discoverysciences@lifetech.com.

88 more kinases now available to order! See the complete list.
Thermo Scientific™

LRRK2 [D1994A] Human Protein

Catalog number:  PR9102A

Related applications:

Protein Assays and Analysis

Back to top

Description

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Certain mutations (e.g. I2020T, G2019S, and R1441C) in this gene have been associated with Parkinson's disease. D1994A is an artificial mutation that renders the kinase catalytically inactive and thus serves as a useful control for activity assays, especially when testing novel substrates.

Related Links:
LRRK2 tools for advancing Parkinson's disease research
Kinase protein portfolio
LanthaScreen® Eu Kinase Binding Assay
LanthaScreen® Activity Assay
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_940980.2
Kinase Group: Ser⁄Thr Kinases: TKL Group
Shipping Condition: Dry Ice
Expression System: Baculovirus
Form: Frozen
Protein Form: Catalytic
Research Category: Drug Development
Species: Human
Validated Application: Kinase Assay
Molecular Weight: 205 kDa
Gene Alias: LRRK2 D1994A
KinaseFamily: LRRK Kinase Family
Protein Tag: GST Tag

Contents & storage

Kinase proteins are shipped on dry ice and should be stored at -80°C.