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ErbB2 (HER2)

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Description

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_004439
Assay Entry: Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity
Kinase Group: Tyrosine Kinases
Shipping Condition: Dry Ice
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate, Z'-LYTE™
Target Entry: ERBB2
Target Gene: V-erb-b2 erythroblastic leukemia viral oncogene homolog 2
Expression System: Baculovirus
Protein Family: Kinases & Inhibitors
Protein Form: Recombinant, Cytoplasmic
Protein Subtype: Receptor Tyrosine Kinases
Research Category: Oncology, Signal Transduction
Species: Human
Validated Application: Kinase Assay
Gene ID (Entrez): 2064
Molecular Weight: 68.6 kDa
Quantity: 10μg
Gene Alias: ErbB2 (HER2), NEU
KinaseFamily: EGF Receptor (ErbB) Kinase Family
Protein Length: aa 676-1255
Protein Tag: His Tag

Contents & storage

Storage Buffer: 50mM Tris, pH 7.5, 150mM NaCl, 0.5mM EDTA, 0.01% CHAPS, 2mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.