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ABL1 [Y253F] Recombinant Human Protein

Catalog number:  PV3863

Related applications:

Pharma & Biopharma

| Protein Assays and Analysis

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Description

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. The Y253F mutant is a Gleevec resistant form of ABL1.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_005148.2, Y253F
Assay Entry: Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity, Biochemical binding/kinetic
Kinase Group: Tyrosine Kinases
Shipping Condition: Dry Ice
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Target Entry: ABL1 Y253F
Target Gene: c-abl oncogene 1, receptor tyrosine kinase
Expression System: Baculovirus
Protein Family: Kinases & Inhibitors
Protein Form: Full Length, Recombinant, Cytoplasmic
Protein Subtype: Cytoplasmic Tyrosine Kinases
Research Category: Oncology, Signal Transduction
Species: Human
Validated Application: Kinase Assay
Gene ID (Entrez): 25, 9586
Molecular Weight: 125.4 kDa
Gene Alias: ABL1 Y253F, ABL, c-ABL
KinaseFamily: ABL Kinase Family
Protein Length: Full Length (Y253F)
Protein Tag: His Tag

Contents & storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% NP-40, 2 mM DTT and 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.