ALK Recombinant Human Protein

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Description

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily. It is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neurblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration.

Learn more about our kinase proteins >

Related Links:

LanthaScreen® Kinase Activity Assay
LanthaScreen® Eu Kinase Binding Assay
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_004295,NP_004295.2, J1461V
Expression: Baculovirus
Gene Aliases: CD246, NBLST3
Gene ID: 114294, 238,238
Kinase Family: ALK Kinase Family
Kinase Group: Tyrosine Kinases
Molecular Weight: 89.9 kDa,90 kDa
Product Size: 10 µg
Protein Form: Active,Cytoplasmic,Recombinant
Protein Length or Portion (a.a.): aa 1058-1620
Protein Tag or Fusion: GST Tag
Research Category: Drug Development
Shipping Condition: Dry Ice
Species: Human
System Compatibility: LanthaScreen® Antibody,LanthaScreen® Substrate,Omnia® Bulk Substrate,Z'-LYTE™
Target Gene: anaplastic lymphoma receptor tyrosine kinase
Validated Application: Kinase Assay

Contents & storage

Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% glycerol

Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.